Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00771
Entry Name
UniProt Accession
Theoretical PI
7.63
Molecular Weight
133367.39
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Tyrosine-protein kinase JAK1
Protein Synonyms/Alias
2.7.10.2; Janus kinase 1; JAK-1;
Gene Name
Jak1
Gene Synonyms/Alias
Created Date
01-OCT-1996
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
542
Canonical
ISFVLKRCCQPKPRE
[1]
S-Palmitoylation
543
Canonical
SFVLKRCCQPKPREI
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Ren W, Jhala US, Du K. Proteomic analysis of protein palmitoylation inadipocytes. Adipocyte. 2013;2(1):17-28.[PMID:23599907]
Functional Description
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Sequence Annotation
Domain: 34 420 FERM.
Domain: 439 542 SH2.
Domain: 582 854 Protein kinase 1.
Domain: 874 1152 Protein kinase 2.
Nucleotide-binding: 880 888 ATP.
Active site: 1002 1002 Proton acceptor.
Binding site: 907 907 ATP.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 3 3 Phosphotyrosine.
Modified residue: 228 228 Phosphoserine.
Modified residue: 1033 1033 Phosphotyrosine; by autocatalysis.
Modified residue: 1034 1034 Phosphotyrosine; by autocatalysis.
Protein Length
1153 AA.
Protein Sequence
(Canonical)
MQYLNIKEDC NAMAFCAKMR SFKKTEVKQV VPEPGVEVTF YLLDREPLRL GSGEYTAEEL  60
CIRAAQECSI SPLCHNLFAL YDESTKLWYA PNRIITVDDK TSLRLHYRMR FYFTNWHGTN  120
DNEQSVWRHS PKKQKNGYEK KRVPEATPLL DASSLEYLFA QGQYDLIKCL APIRDPKTEQ  180
DGHDIENECL GMAVLAISHY AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI  240
NNVFKDFLKE FNNKTICDSS VHDLKVKYLA TLETSTLTKH YGAEIFETSM LLISSENELS  300
RCHSNDSGNV LYEVMVTGNL GIQWRQKPNV VPVEKEKNKL KRKKLEYNKH KKDDERNKLR  360
EEWNNFSYFP EITHIVIKES VVSINKQDNK NMELKLSSRE EALSFVSLVD GYFRLTADAH  420
HYLCTDVAPP LIVHNIQNGC HGPICTEYAI NKLRQEGSEE GMYVLRWSCT DFDNILMTVT  480
CFEKSEVLGG QKQFKNFQIE VQKGRYSLHG SMDHFPSLRD LMNHLKKQIL RTDNISFVLK  540
RCCQPKPREI SNLLVATKKA QEWQPVYSMS QLSFDRILKK DIIQGEHLGR GTRTHIYSGT  600
LLDYKDEEGI AEEKKIKVIL KVLDPSHRDI SLAFFEAASM MRQVSHKHIV YLYGVCVRDV  660
ENIMVEEFVE GGPLDLFMHR KSDALTTPWK FKVAKQLASA LSYLEDKDLV HGNVCTKNLL  720
LAREGIDSDI GPFIKLSDPG IPVSVLTRQE CIERIPWIAP ECVEDSKNLS VAADKWSFGT  780
TLWEICYNGE IPLKDKTLIE KERFYESRCR PVTPSCKELA DLMTRCMNYD PNQRPFFRAI  840
MRDINKLEEQ NPDIVSEKQP TTEVDPTHFE KRFLKRIRDL GEGHFGKVEL CRYDPEGDNT  900
GEQVAVKSLK PESGGNHIAD LKKEIEILRN LYHENIVKYK GICMEDGGNG IKLIMEFLPS  960
GSLKEYLPKN KNKINLKQQL KYAIQICKGM DYLGSRQYVH RDLAARNVLV ESEHQVKIGD  1020
FGLTKAIETD KEYYTVKDDR DSPVFWYAPE CLIQCKFYIA SDVWSFGVTL HELLTYCDSD  1080
FSPMALFLKM IGPTHGQMTV TRLVKTLKEG KRLPCPPNCP DEVYQLMRKC WEFQPSNRTT  1140
FQNLIEGFEA LLK                                                     1153
FASTA
(Canonical)
>LipidDB-10090-00771|P52332
MQYLNIKEDCNAMAFCAKMRSFKKTEVKQVVPEPGVEVTFYLLDREPLRLGSGEYTAEEL
CIRAAQECSISPLCHNLFALYDESTKLWYAPNRIITVDDKTSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVHDLKVKYLATLETSTLTKHYGAEIFETSMLLISSENELS
RCHSNDSGNVLYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLEYNKHKKDDERNKLR
EEWNNFSYFPEITHIVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGT
LLDYKDEEGIAEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
FSPMALFLKMIGPTHGQMTVTRLVKTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTT
FQNLIEGFEALLK
Gene Ontology
GO:0005856; C:cytoskeleton; IEA:InterPro
GO:0005829; C:cytosol; TAS:Reactome
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC
GO:0004713; F:protein tyrosine kinase activity; IDA:MGI
GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI
GO:0007167; P:enzyme linked receptor protein signaling pathway; IDA:MGI
GO:0038110; P:interleukin-2-mediated signaling pathway; ISS:UniProtKB
GO:0035556; P:intracellular signal transduction; IDA:MGI
GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI
GO:0046677; P:response to antibiotic; ISO:MGI
Interpro
InterPro; IPR019749; Band_41_domain
InterPro; IPR019748; FERM_central
InterPro; IPR000299; FERM_domain
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom
InterPro; IPR000980; SH2
InterPro; IPR008266; Tyr_kinase_AS
InterPro; IPR020635; Tyr_kinase_cat_dom
InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2
InterPro; IPR020776; Tyr_kinase_non-rcpt_Jak1
Pfam
Pfam; PF07714; Pkinase_Tyr;
SMART
SMART; SM00295; B41;
SMART; SM00252; SH2;
SMART; SM00219; TyrKc;
PROSITE
PROSITE; PS50057; FERM_3;
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00109; PROTEIN_KINASE_TYR;
PROSITE; PS50001; SH2;
PRINTS
PRINTS; PR01823; JANUSKINASE;
PRINTS; PR01824; JANUSKINASE1;
PRINTS; PR00109; TYRKINASE;