LipidDB ID

LipidDB-10090-00751

Entry Name

UniProt Accession

P15379; Q05732; Q61395; Q62060; Q62061; Q62062; Q62063; Q62408; Q62409; Q64296; Q99J14; Q9QYX8;

Theoretical PI

4.82

Molecular Weight

85617.15

Genbank Protein ID

CAA46883.1; CAA46882.1; CAA46881.1; CAA46880.1; AAA39922.1; AAA37406.1; AAA37407.1; CAB61888.1; AAH05676.1; BAC32269.1; AAA39923.1; CAA49380.1; AAA37145.1; AAC52804.1; AAB08756.1; AAC52805.1; AAC52806.1;

Genbank Nucleotide ID

X66084; X66083; X66082; X66081; M30655; M27129; M27130; AJ251594; BC005676; AK045226; J05163; X69724; L13611; U57610; U57611; U57612; U57612;

Protein Name

CD44 antigen

Protein Synonyms/Alias

Extracellular matrix receptor III; ECMR-III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Lymphocyte antigen 24; Ly-24; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD44;

Gene Name

Cd44

Gene Synonyms/Alias

Ly-24;

Created Date

01-APR-1990

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis (By similarity).

Sequence Annotation

Topological domain: 23 685 Extracellular.
Transmembrane: 686 706 Helical.
Topological domain: 707 778 Cytoplasmic.
Domain: 34 123 Link.
Region: 227 685 Stem.
Binding site: 43 43 Hyaluronan.
Binding site: 80 80 Hyaluronan.
Binding site: 81 81 Hyaluronan.
Binding site: 107 107 Hyaluronan.
Modified residue: 410 410 Sulfotyrosine.
Modified residue: 708 708 Phosphoserine; by PKC.
Modified residue: 726 726 Phosphothreonine.
Modified residue: 733 733 Phosphoserine.
Modified residue: 742 742 Phosphoserine.

Protein Length

778 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016323; C:basolateral plasma membrane; IDA:MGI
GO:0009986; C:cell surface; IDA:MGI
GO:0009897; C:external side of plasma membrane; IDA:MGI
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IDA:MGI
GO:0005540; F:hyaluronic acid binding; IDA:MGI
GO:0060442; P:branching involved in prostate gland morphogenesis; IMP:MGI
GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI
GO:0007155; P:cell adhesion; IDA:MGI
GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IMP:BHF-UCL
GO:1902166; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:BHF-UCL
GO:0002906; P:negative regulation of mature B cell apoptotic process; IDA:BHF-UCL
GO:0002821; P:positive regulation of adaptive immune response; NAS:BHF-UCL
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:BHF-UCL
GO:0010628; P:positive regulation of gene expression; IGI:MGI
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL
GO:0016055; P:Wnt signaling pathway; IDA:MGI
GO:0002246; P:wound healing involved in inflammatory response; IMP:MGI

Interpro

InterPro; IPR016186; C-type_lectin-like
InterPro; IPR016187; C-type_lectin_fold
InterPro; IPR001231; CD44_antigen
InterPro; IPR000538; Link

Pfam

Pfam; PF00193; Xlink;

SMART

SMART; SM00445; LINK;

PROSITE

PROSITE; PS01241; LINK_1;
PROSITE; PS50963; LINK_2;

PRINTS

PRINTS; PR00658; CD44;
PRINTS; PR01265; LINKMODULE;