Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00733
Entry Name
UniProt Accession
Theoretical PI
5.5
Molecular Weight
40538.15
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Guanine nucleotide-binding protein G(k) subunit alpha
Protein Synonyms/Alias
G(i) alpha-3;
Gene Name
Gnai3
Gene Synonyms/Alias
Created Date
17-JAN-2003
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
3
Canonical
*****MGCTLSAEDK
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor- regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Sequence Annotation
Nucleotide-binding: 40 47 GTP.
Nucleotide-binding: 175 181 GTP.
Nucleotide-binding: 200 204 GTP.
Nucleotide-binding: 269 272 GTP.
Metal binding site: 47 47 Magnesium.
Metal binding site: 181 181 Magnesium.
Binding site: 326 326 GTP; via amide nitrogen.
Protein Length
354 AA.
Protein Sequence
(Canonical)
MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV KQMKIIHEDG  60
YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGESAR ADDARQLFVL AGSAEEGVMT  120
SELAGVIKRL WRDGGVQACF SRSREYQLND SASYYLNDLD RISQTNYIPT QQDVLRTRVK  180
TTGIVETHFT FKELYFKMFD VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM  240
NRMHESMKLF DSICNNKWFT DTSIILFLNK KDLFEEKIKR SPLTICYPEY TGSNTYEEAA  300
AYIQCQFEDL NRRKDTKEVY THFTCATDTK NVQFVFDAVT DVIIKNNLKE CGLY        354
FASTA
(Canonical)
>LipidDB-10090-00733|Q9DC51
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGESARADDARQLFVLAGSAEEGVMT
SELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQTNYIPTQQDVLRTRVK
TTGIVETHFTFKELYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAA
AYIQCQFEDLNRRKDTKEVYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
Gene Ontology
GO:0005813; C:centrosome; ISS:UniProtKB
GO:0005737; C:cytoplasm; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005794; C:Golgi apparatus; IDA:MGI
GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0005765; C:lysosomal membrane; IEA:Ensembl
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0030496; C:midbody; ISS:UniProtKB
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0042588; C:zymogen granule; IEA:Ensembl
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0031821; F:G-protein coupled serotonin receptor binding; IBA:RefGenome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IBA:RefGenome
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0051301; P:cell division; ISS:UniProtKB
GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI
GO:0006906; P:vesicle fusion; IEA:Ensembl
Interpro
InterPro; IPR001408; Gprotein_alpha_I
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF00503; G-alpha;
SMART
SMART; SM00275; G_alpha;
PROSITE
PRINTS
PRINTS; PR00318; GPROTEINA;
PRINTS; PR00441; GPROTEINAI;