Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00680
Entry Name
UniProt Accession
Theoretical PI
5.98
Molecular Weight
31802.73
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Phospholipid scramblase 3
Protein Synonyms/Alias
PL scramblase 3; Ca(2+)-dependent phospholipid scramblase 3;
Gene Name
Plscr3
Gene Synonyms/Alias
Created Date
20-JUN-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
127
Canonical
AAEESNCCARLCCGA
[1]
S-Palmitoylation
131
Canonical
SNCCARLCCGARRPF
[1]
S-Palmitoylation
132
Canonical
NCCARLCCGARRPFR
[1]
S-Palmitoylation
163
Canonical
PLHCGCSCCPCGLQE
[1]
S-Palmitoylation
164
Canonical
LHCGCSCCPCGLQEM
[1]
S-Palmitoylation
166
Canonical
CGCSCCPCGLQEMEV
[1]
S-Palmitoylation
212
Canonical
VLRVVGPCWTCGCGT
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mitochondrial damages.
Sequence Annotation
Topological domain: 1 266 Cytoplasmic.
Transmembrane: 267 283 Helical.
Topological domain: 284 296 Extracellular.
Region: 1 58 Proline-rich domain (PRD).
Motif: 7 15 SH3-binding 1.
Motif: 15 18 WW-binding.
Motif: 21 27 SH3-binding 2.
Motif: 66 71 SH3-binding 3.
Protein Length
296 AA.
Protein Sequence
(Canonical)
MAGYLPPKGY APSPPPPYPV PSGYPEPVAL HPGPGQAPVP TQVPAPAPGF ALFPSPGPVA  60
PGPPAPFVPL PGVPPGLEFL VQIDQILIHQ KAERVETFLG WETCNMYELR SGTGQQLGQA  120
AEESNCCARL CCGARRPFRI RLADPGDREV LRLLRPLHCG CSCCPCGLQE MEVQAPPGTT  180
IGHVLQTWHP FLPKFSILDA DRQPVLRVVG PCWTCGCGTD TNFEVKTKDE SRSVGRISKQ  240
WGGLLREALT DADDFGLQFP VDLDVKVKAV LLGATFLIDY MFFEKRGGAG PSAITS      296
FASTA
(Canonical)
>LipidDB-10090-00680|Q9JIZ9
MAGYLPPKGYAPSPPPPYPVPSGYPEPVALHPGPGQAPVPTQVPAPAPGFALFPSPGPVA
PGPPAPFVPLPGVPPGLEFLVQIDQILIHQKAERVETFLGWETCNMYELRSGTGQQLGQA
AEESNCCARLCCGARRPFRIRLADPGDREVLRLLRPLHCGCSCCPCGLQEMEVQAPPGTT
IGHVLQTWHPFLPKFSILDADRQPVLRVVGPCWTCGCGTDTNFEVKTKDESRSVGRISKQ
WGGLLREALTDADDFGLQFPVDLDVKVKAVLLGATFLIDYMFFEKRGGAGPSAITS
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IEA:UniProtKB-KW
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW
GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB
GO:0042632; P:cholesterol homeostasis; IMP:MGI
GO:0042593; P:glucose homeostasis; IMP:MGI
Interpro
InterPro; IPR005552; Scramblase
Pfam
Pfam; PF03803; Scramblase;
SMART
PROSITE
PRINTS