LipidDB ID

LipidDB-10090-00668

Entry Name

UniProt Accession

O70274; Q3U1K7;

Theoretical PI

8.67

Molecular Weight

19127.2

Genbank Protein ID

AAC15874.1; BAC28149.1; BAC32217.1; BAE33489.1; AAH86794.1; AAH87551.1;

Genbank Nucleotide ID

AF035644; AK033092; AK045093; AK155895; BC086794; BC087551;

Protein Name

Protein tyrosine phosphatase type IVA 2

Protein Synonyms/Alias

3.1.3.48; Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2;

Gene Name

Ptp4a2

Gene Synonyms/Alias

Prl2;

Created Date

05-JUL-2005

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Zeng Q, Si X, Horstmann H, Xu Y, Hong W, Pallen CJ. Prenylation-dependentassociation of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasmamembrane and the early endosome. J Biol Chem. 2000 Jul 14;275(28):21444-52.[PMID:10747914]

Functional Description

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity).

Sequence Annotation

Domain: 79 145 Tyrosine-protein phosphatase.
Region: 102 107 Phosphate binding.
Active site: 69 69 Proton donor.
Active site: 101 101 Phosphocysteine intermediate.
Binding site: 107 107 Substrate.
Modified residue: 164 164 Cysteine methyl ester.

Protein Length

167 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC

Interpro

InterPro; IPR029021; Prot-tyrosine_phosphatase-like
InterPro; IPR000387; Tyr/Dual-sp_Pase
InterPro; IPR000242; Tyr_Pase_rcpt/non-rcpt

Pfam

Pfam; PF00102; Y_phosphatase;

SMART

PROSITE

PROSITE; PS50056; TYR_PHOSPHATASE_2;

PRINTS