Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00628
Entry Name
UniProt Accession
Theoretical PI
8.56
Molecular Weight
26334.52
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
MICOS complex subunit Mic19
Protein Synonyms/Alias
Coiled-coil-helix-coiled-coil-helix domain-containing protein 3;
Gene Name
Chchd3
Gene Synonyms/Alias
Mic19;
Created Date
12-APR-2005
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
2
Canonical
******MGGTASTRR
[1]
N-Myristoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, EllismanMH, Taylor SS. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem. 2011 Jan28;286(4):2918-32. doi: 10.1074/jbc.M110.171975. Epub 2010 Nov 16.[PMID:21081504]
Functional Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (By similarity).
Sequence Annotation
Domain: 176 217 CHCH.
Modified residue: 49 49 Phosphotyrosine.
Modified residue: 50 50 Phosphoserine.
Modified residue: 142 142 N6-acetyllysine.
Protein Length
227 AA.
Protein Sequence
(Canonical)
MGGTASTRRV TFEADENENI TVVKGIRLSE NVIDRMKESS PSGSKSQRYS SVYGASVSDE  60
DLKRRVAEEL ALEQAKKESE HQRRLKQARD LERERAAANE QLTRAVLRER ISSEEERMKA  120
KHLARQLEEK DRVMRKQDAF YKEQLARLEE RSSEFYKVTT EEYQKAAEEV EAKFKRYEYH  180
PVCADLQTKI LQCYRQNTQQ TLSCSALASQ YMHCVNHAKQ SMLEKGG                227
FASTA
(Canonical)
>LipidDB-10090-00628|Q9CRB9
MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDE
DLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKA
KHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYH
PVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG
Gene Ontology
GO:0005737; C:cytoplasm; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB
GO:0005739; C:mitochondrion; IDA:UniProtKB
GO:0005634; C:nucleus; ISS:UniProtKB
GO:0019902; F:phosphatase binding; ISS:UniProtKB
GO:0032947; F:protein complex scaffold; IMP:UniProtKB
GO:0001227; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; ISS:UniProtKB
GO:0007007; P:inner mitochondrial membrane organization; IEA:Ensembl
GO:0008053; P:mitochondrial fusion; IEA:Ensembl
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB
Interpro
InterPro; IPR007964; DUF737
Pfam
Pfam; PF05300; DUF737;
SMART
PROSITE
PRINTS