LipidDB ID

LipidDB-10090-00601

Entry Name

UniProt Accession

P22723; Q91V50; Q91VA8;

Theoretical PI

8.88

Molecular Weight

55098.51

Genbank Protein ID

AAB59635.1; AAA37653.1; AAK71573.1; AAK71574.1; AAK71575.1; AAK71576.1; AAK71577.1; AAK71578.1; AAK71579.1; AAK71580.1; AAK71581.1; AAK71582.1; AAK71583.1; AAK71584.1; AAK71585.1; AAK71586.1; AAK71587.1; AAK71588.1; AAK71589.1; AAK71590.1; AAK71591.1; AAK71592.1; AAK71593.1; AAK71594.1; AAK71595.1; AAK71596.1; AAK71597.1; AAK71598.1; AAK71599.1; AAK71600.1; AAH31762.1;

Genbank Nucleotide ID

M86572; M62374; AF233775; AF233776; AF233777; AF233778; AF233779; AF233780; AF233781; AF233782; AF233783; AF233784; AF233785; AF233786; AF233787; AF233788; AF233789; AF233790; AF233791; AF233792; AF233793; AF233794; AF233795; AF233796; AF233797; AF233798; AF233799; AF233800; AF233801; AF233802; BC031762;

Protein Name

Gamma-aminobutyric acid receptor subunit gamma-2

Protein Synonyms/Alias

GABA(A) receptor subunit gamma-2;

Gene Name

Gabrg2

Gene Synonyms/Alias

Created Date

01-AUG-1991

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Rathenberg J, Kittler JT, Moss SJ. Palmitoylation regulates the clustering andcell surface stability of GABAA receptors. Mol Cell Neurosci. 2004Jun;26(2):251-7.[PMID:15207850]

Functional Description

Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel.

Sequence Annotation

Topological domain: 39 272 Extracellular.
Transmembrane: 273 295 Helical.
Transmembrane: 299 321 Helical.
Transmembrane: 333 355 Helical.
Topological domain: 356 450 Cytoplasmic.
Transmembrane: 451 474 Helical.
Modified residue: 381 381 Phosphoserine; by PKC.

Protein Length

474 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030424; C:axon; IDA:MGI
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW
GO:0005737; C:cytoplasm; IEA:Ensembl
GO:0032590; C:dendrite membrane; IEA:Ensembl
GO:1902711; C:GABA-A receptor complex; IMP:UniProtKB
GO:0060077; C:inhibitory synapse; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IMP:UniProtKB
GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW
GO:0005254; F:chloride channel activity; IMP:UniProtKB
GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro
GO:0004890; F:GABA-A receptor activity; IMP:UniProtKB
GO:0030534; P:adult behavior; IMP:MGI
GO:0071420; P:cellular response to histamine; IDA:UniProtKB
GO:1902476; P:chloride transmembrane transport; IMP:UniProtKB
GO:0007214; P:gamma-aminobutyric acid signaling pathway; IDA:MGI
GO:0009791; P:post-embryonic development; IMP:MGI
GO:0007268; P:synaptic transmission; IDA:MGI
GO:0051932; P:synaptic transmission, GABAergic; IEA:Ensembl

Interpro

InterPro; IPR006028; GABAA/Glycine_rcpt
InterPro; IPR005439; GABBAg2_rcpt
InterPro; IPR005437; GABBAg_rcpt
InterPro; IPR006202; Neur_chan_lig-bd
InterPro; IPR006201; Neur_channel
InterPro; IPR006029; Neurotrans-gated_channel_TM
InterPro; IPR018000; Neurotransmitter_ion_chnl_CS

Pfam

Pfam; PF02931; Neur_chan_LBD;
Pfam; PF02932; Neur_chan_memb;

SMART

PROSITE

PROSITE; PS00236; NEUROTR_ION_CHANNEL;

PRINTS

PRINTS; PR00253; GABAARECEPTR;
PRINTS; PR01620; GABAARGAMMA;
PRINTS; PR01622; GABAARGAMMA2;
PRINTS; PR00252; NRIONCHANNEL;