Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00600
Entry Name
UniProt Accession
Theoretical PI
7.78
Molecular Weight
101569.08
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Glutamate receptor 1
Protein Synonyms/Alias
GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic, AMPA 1; GluA1;
Gene Name
Gria1
Gene Synonyms/Alias
Glur1;
Created Date
01-NOV-1991
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
603
Canonical
GAFMQQGCDISPRSL
[1]
S-Palmitoylation
829
Canonical
LVALIEFCYKSRSES
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptorsubunit trafficking by palmitoylation of two distinct sites. Neuron. 2005 Sep1;47(5):709-23.[PMID:16129400]
Functional Description
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Sequence Annotation
Topological domain: 19 536 Extracellular.
Transmembrane: 537 557 Helical.
Topological domain: 558 584 Cytoplasmic.
Topological domain: 604 609 Cytoplasmic.
Transmembrane: 610 630 Helical.
Topological domain: 631 805 Extracellular.
Transmembrane: 806 826 Helical; Name=M4.
Topological domain: 827 907 Cytoplasmic.
Region: 492 494 Glutamate binding.
Region: 668 669 Glutamate binding.
Motif: 904 907 PDZ-binding.
Binding site: 464 464 Glutamate.
Binding site: 499 499 Glutamate.
Binding site: 719 719 Glutamate.
Modified residue: 645 645 Phosphoserine.
Modified residue: 710 710 Phosphoserine.
Modified residue: 849 849 Phosphoserine.
Modified residue: 863 863 Phosphoserine.
Protein Length
907 AA.
Protein Sequence
(Canonical)
MPYIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID  60
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ  120
FVLQLRPELQ EALISIIDHY KWQTFVYIYD ADRGLSVLQR VLDTAAEKNW QVTAVNILTT  180
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIVKLE KNGIGYHYIL ANLGFMDIDL  240
NKFKESGANV TGFQLVNYTD TIPARIMQQW RTSDARDHTR VDWKRPKYTS ALTYDGVKVM  300
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR  360
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV  420
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE  480
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW  540
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ  600
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA  660
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES  720
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRGPV NLAVLKLSEQ GVLDKLKSKW  780
WYDKGECGSK DSGSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK  840
GFCLIPQQSI NEAIRTSTLP RNSGAGASGG SGSGENGRVV SQDFPKSMQS IPCMSHSSGM  900
PLGATGL                                                            907
FASTA
(Canonical)
>LipidDB-10090-00600|P23818
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKW
WYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGM
PLGATGL
Gene Ontology
GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:MGI
GO:0044308; C:axonal spine; IDA:MGI
GO:0030054; C:cell junction; IEA:UniProtKB-KW
GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0030425; C:dendrite; IDA:UniProtKB
GO:0032590; C:dendrite membrane; IDA:BHF-UCL
GO:0043197; C:dendritic spine; IDA:UniProtKB
GO:0005783; C:endoplasmic reticulum; IDA:MGI
GO:0008328; C:ionotropic glutamate receptor complex; IDA:BHF-UCL
GO:0016020; C:membrane; IDA:MGI
GO:0043005; C:neuron projection; IDA:BHF-UCL
GO:0044309; C:neuron spine; IDA:BHF-UCL
GO:0043025; C:neuronal cell body; IDA:BHF-UCL
GO:0005886; C:plasma membrane; IDA:BHF-UCL
GO:0014069; C:postsynaptic density; IDA:UniProtKB
GO:0045211; C:postsynaptic membrane; IDA:BHF-UCL
GO:0045202; C:synapse; ISO:MGI
GO:0008021; C:synaptic vesicle; IDA:MGI
GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB
GO:0005234; F:extracellular-glutamate-gated ion channel activity; IBA:RefGenome
GO:0034220; P:ion transmembrane transport; IBA:RefGenome
GO:0035235; P:ionotropic glutamate receptor signaling pathway; IBA:RefGenome
GO:0007616; P:long-term memory; IMP:UniProtKB
GO:0031623; P:receptor internalization; IMP:UniProtKB
GO:0007268; P:synaptic transmission; IGI:MGI
GO:0035249; P:synaptic transmission, glutamatergic; IBA:RefGenome
Interpro
InterPro; IPR001828; ANF_lig-bd_rcpt
InterPro; IPR019594; Glu_rcpt_Glu/Gly-bd
InterPro; IPR001320; Iontro_glu_rcpt
InterPro; IPR001508; NMDA_rcpt
InterPro; IPR028082; Peripla_BP_I
Pfam
Pfam; PF01094; ANF_receptor;
Pfam; PF00060; Lig_chan;
Pfam; PF10613; Lig_chan-Glu_bd;
SMART
SMART; SM00918; Lig_chan-Glu_bd;
SMART; SM00079; PBPe;
PROSITE
PRINTS
PRINTS; PR00177; NMDARECEPTOR;