LipidDB-10090-00578

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-00578

Entry Name

5HT4R_MOUSE

UniProt Accession

P97288; O89003; O89004; Q3URB5; Q9R2A4;

Theoretical PI

8.49

Molecular Weight

43961.85

Genbank Protein ID

CAA70773.1; CAA70775.1; CAA70776.1; CAA09598.1; BAE24750.1; BAE24773.1; EDL09743.1;

Genbank Nucleotide ID

Y09585; Y09587; Y09588; AJ011369; AK141587; AK141625; CH466528;

Protein Name

5-hydroxytryptamine receptor 4

Protein Synonyms/Alias

5-HT-4; 5-HT4; Serotonin receptor 4;

Gene Name

Htr4

Gene Synonyms/Alias

Created Date

15-JUL-1998

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
328	Isoform 2	RAFLIILCCDDERYK	[1]	S-Palmitoylation
329	Isoform 2	AFLIILCCDDERYKR	[1]	S-Palmitoylation
386	Isoform 2	DPESLESCF******	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Salaün C, Gould GW, Chamberlain LH. The SNARE proteins SNAP-25 and SNAP-23display different affinities for lipid rafts in PC12 cells. Regulation bydistinct cysteine-rich domains. J Biol Chem. 2005 Jan 14;280(2):1236-40. Epub2004 Nov 12.[PMID:15542596]

Functional Description

This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase (By similarity).

Sequence Annotation

Topological domain: 1 19 Extracellular.
Transmembrane: 20 40 Helical; Name=1.
Topological domain: 41 58 Cytoplasmic.
Transmembrane: 59 79 Helical; Name=2.
Topological domain: 80 93 Extracellular.
Transmembrane: 94 116 Helical; Name=3.
Topological domain: 117 137 Cytoplasmic.
Transmembrane: 138 158 Helical; Name=4.
Topological domain: 159 192 Extracellular.
Transmembrane: 193 213 Helical; Name=5.
Topological domain: 214 260 Cytoplasmic.
Transmembrane: 261 281 Helical; Name=6.
Topological domain: 282 294 Extracellular.
Transmembrane: 295 315 Helical; Name=7.
Topological domain: 316 388 Cytoplasmic.

Protein Length

388 AA.

Protein Sequence
(Isoform 2)

MDKLDANVSS NEGFRSVEKV VLLTFLAVVI LMAILGNLLV MVAVCRDRQL RKIKTNYFIV  60
SLAFADLLVS VLVMPFGAIE LVQDIWAYGE MFCLVRTSLD VLLTTASIFH LCCISLDRYY  120
AICCQPLVYR NKMTPLRIAL MLGGCWVLPM FISFLPIMQG WNNIGIVDVI EKRKFSHNSN  180
STWCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAQQIQMLQ RAGATSESRP  240
QPADQHSTHR MRTETKAAKT LCVIMGCFCF CWAPFFVTNI VDPFIDYTVP EQVWTAFLWL  300
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYKRPPIL GQTVPCSTTT INGSTHVLRY  360
TVLHSGHHQE LEKLPIHNDP ESLESCF                                      387

FASTA
(Isoform 2)

>LipidDB-10090-00578|P97288-2
MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSN
STWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP
QPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRY
TVLHSGHHQELEKLPIHNDPESLESCF

Gene Ontology

GO:0005768; C:endosome; IEA:UniProtKB-KW
GO:0005887; C:integral component of plasma membrane; IEA:InterPro
GO:0004993; F:serotonin receptor activity; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0032098; P:regulation of appetite; IEA:InterPro
GO:0007268; P:synaptic transmission; IEA:InterPro

Interpro

InterPro; IPR001520; 5HT4_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR01059; 5HT4RECEPTR;
PRINTS; PR00237; GPCRRHODOPSN;