LipidDB-10090-00574

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-00574

Entry Name

STOM_MOUSE

UniProt Accession

P54116; O88988; Q3UP81; Q60744; Q62455;

Theoretical PI

6.46

Molecular Weight

31375.27

Genbank Protein ID

AAA75024.1; CAA62503.1; AAB18857.1; AAB18857.1; AAB18857.1; AAB18857.1; AAB18857.1; AAB18857.1; AAB18857.1; AAC64173.1; BAE23930.1; BAE25516.1; BAE28708.1; BAE29028.1; BAE29103.1; BAE29219.1; BAE30137.1;

Genbank Nucleotide ID

U17297; X91043; U50999; U50993; U50994; U50995; U50996; U50997; U50998; AF093620; AK139242; AK143724; AK148975; AK149689; AK149821; AK149991; AK151129;

Protein Name

Erythrocyte band 7 integral membrane protein

Protein Synonyms/Alias

Protein 7.2b; Stomatin;

Gene Name

Stom

Gene Synonyms/Alias

Epb7.2; Epb72;

Created Date

01-OCT-1996

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
30	Canonical	SKTELGACGWILVAA	[1]	S-Palmitoylation
53	Canonical	FPISIWICIKIVKEY	[1]	S-Palmitoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

Sequence Annotation

Topological domain: 1 31 Cytoplasmic.
Topological domain: 53 284 Cytoplasmic.
Region: 265 273 Required for homooligomerization.
Region: 267 269 Required for lipid raft association.
Region: 273 284 Interaction with LANCL1.
Modified residue: 161 161 Phosphoserine.
Modified residue: 244 244 Phosphoserine.

Protein Length

284 AA.

Protein Sequence
(Canonical)

MSDKRQSSHV QSQRIPESFR ENSKTELGAC GWILVAASFF FVIITFPISI WICIKIVKEY  60
ERVIIFRLGR ILQGGAKGPG LFFILPCTDS LIKVDMRTIS FDIPPQEVLT KDSVTISVDG  120
VVYYRVQNAT LAVANITNAD SATRLLAQTT LRNALGTKNL SQILSDREEI AHHMQSTLDD  180
ATDDWGIKVE RVEIKDVKLP VQLQRAMAAE AEAAREARAK VIAAEGEMNA SRALKEASMV  240
ITESPAALQL RYLQTLTTIA AEKNSTIVFP LPVDMLQGIM GSNH                   284

FASTA
(Canonical)

>LipidDB-10090-00574|P54116
MSDKRQSSHVQSQRIPESFRENSKTELGACGWILVAASFFFVIITFPISIWICIKIVKEY
ERVIIFRLGRILQGGAKGPGLFFILPCTDSLIKVDMRTISFDIPPQEVLTKDSVTISVDG
VVYYRVQNATLAVANITNADSATRLLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDD
ATDDWGIKVERVEIKDVKLPVQLQRAMAAEAEAAREARAKVIAAEGEMNASRALKEASMV
ITESPAALQLRYLQTLTTIAAEKNSTIVFPLPVDMLQGIMGSNH

Gene Ontology

GO:0072562; C:blood microparticle; IEA:Ensembl
GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW
GO:0005856; C:cytoskeleton; ISS:UniProtKB
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB
GO:0045121; C:membrane raft; ISS:UniProtKB
GO:0042802; F:identical protein binding; IPI:IntAct
GO:0042803; F:protein homodimerization activity; IPI:UniProtKB
GO:0051260; P:protein homooligomerization; ISS:UniProtKB
GO:1901585; P:regulation of acid-sensing ion channel activity; IDA:UniProtKB
GO:0034765; P:regulation of ion transmembrane transport; IDA:UniProtKB

Interpro

InterPro; IPR001107; Band_7
InterPro; IPR018080; Band_7/stomatin-like_CS
InterPro; IPR028515; Stomatin
InterPro; IPR001972; Stomatin_fam

Pfam

Pfam; PF01145; Band_7;

SMART

SMART; SM00244; PHB;

PROSITE

PROSITE; PS01270; BAND_7;

PRINTS

PRINTS; PR00721; STOMATIN;