Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00537
Entry Name
UniProt Accession
Theoretical PI
8.98
Molecular Weight
49915.6
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
5-hydroxytryptamine receptor 7
Protein Synonyms/Alias
5-HT-7; 5-HT7; 5-HT-X; Serotonin receptor 7;
Gene Name
Htr7
Gene Synonyms/Alias
Created Date
01-OCT-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
404
Canonical
TYRSLLQCQYRNINR
[1]
S-Palmitoylation
438
Canonical
SEFVLQNCDHCGKKG
[1]
S-Palmitoylation
441
Canonical
VLQNCDHCGKKGHDT
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Kvachnina E, Dumuis A, Wlodarczyk J, Renner U, Cochet M, Richter DW,Ponimaskin E. Constitutive Gs-mediated, but not G12-mediated, activity of the5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of itsC-terminal domain. Biochim Biophys Acta. 2009 Nov;1793(11):1646-55. doi:10.1016/j.bbamcr.2009.08.008. Epub 2009 Aug 26.[PMID:19715731]
Functional Description
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Sequence Annotation
Topological domain: 1 84 Extracellular.
Transmembrane: 85 111 Helical; Name=1.
Topological domain: 112 121 Cytoplasmic.
Transmembrane: 122 147 Helical; Name=2.
Topological domain: 148 159 Extracellular.
Transmembrane: 160 181 Helical; Name=3.
Topological domain: 182 201 Cytoplasmic.
Transmembrane: 202 225 Helical; Name=4.
Topological domain: 226 240 Extracellular.
Transmembrane: 241 263 Helical; Name=5.
Topological domain: 264 331 Cytoplasmic.
Transmembrane: 332 355 Helical; Name=6.
Topological domain: 356 367 Extracellular.
Transmembrane: 368 390 Helical; Name=7.
Topological domain: 391 448 Cytoplasmic.
Protein Length
448 AA.
Protein Sequence
(Canonical)
MMDVNSSGRP DLYGHLRSLI LPEVGRRLQD LSPDGGAHSV VSSWMPHLLS GFPEVTASPA  60
PTWDAPPDNV SGCGEQINYG RVEKVVIGSI LTLITLLTIA GNCLVVISVC FVKKLRQPSN  120
YLIVSLALAD LSVAVAVMPF VSVTDLIGGK WIFGHFFCNV FIAMDVMCCT ASIMTLCVIS  180
IDRYLGITRP LTYPVRQNGK CMAKMILSVW LLSASITLPP LFGWAQNVND DKVCLISQDF  240
GYTIYSTAVA FYIPMSVMLF MYYQIYKAAR KSAAKHKFSG FPRVQPESVI SLNGVVKLQK  300
EVEECANLSR LLKHERKNIS IFKREQKAAT TLGIIVGAFT VCWLPFFLLS TARPFICGTS  360
CSCIPLWVER TCLWLGYANS LINPFIYAFF NRDLRTTYRS LLQCQYRNIN RKLSAAGMHE  420
ALKLAERPER SEFVLQNCDH CGKKGHDT                                     448
FASTA
(Canonical)
>LipidDB-10090-00537|P32304
MMDVNSSGRPDLYGHLRSLILPEVGRRLQDLSPDGGAHSVVSSWMPHLLSGFPEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFSGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNCDHCGKKGHDT
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004993; F:serotonin receptor activity; IEA:InterPro
GO:0007623; P:circadian rhythm; IEA:InterPro
GO:0006939; P:smooth muscle contraction; IEA:InterPro
GO:0007268; P:synaptic transmission; IEA:InterPro
GO:0042310; P:vasoconstriction; IEA:InterPro
Interpro
InterPro; IPR001069; 5HT_7_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR00652; 5HT7RECEPTR;
PRINTS; PR00237; GPCRRHODOPSN;