LipidDB ID

LipidDB-10090-00531

Entry Name

UniProt Accession

P21279; Q6PFF5;

Theoretical PI

5.48

Molecular Weight

42158.09

Genbank Protein ID

AAA63306.1; AAH57583.1;

Genbank Nucleotide ID

M55412; BC057583;

Protein Name

Guanine nucleotide-binding protein G(q) subunit alpha

Protein Synonyms/Alias

Guanine nucleotide-binding protein alpha-q;

Gene Name

Gnaq

Gene Synonyms/Alias

Created Date

01-MAY-1991

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR. Palmitoylation isrequired for signaling functions and membrane attachment of Gq alpha and Gsalpha. J Biol Chem. 1993 Nov 25;268(33):25001-8.[PMID:8227063]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).

Sequence Annotation

Nucleotide-binding: 46 53 GTP.
Nucleotide-binding: 180 186 GTP.
Nucleotide-binding: 205 209 GTP.
Nucleotide-binding: 274 277 GTP.
Metal binding site: 53 53 Magnesium.
Metal binding site: 186 186 Magnesium.
Binding site: 331 331 GTP; via amide nitrogen.

Protein Length

359 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0005765; C:lysosomal membrane; IEA:Ensembl
GO:0016020; C:membrane; IDA:MGI
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0005096; F:GTPase activator activity; IBA:RefGenome
GO:0003924; F:GTPase activity; IBA:RefGenome
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0031826; F:type 2A serotonin receptor binding; IBA:RefGenome
GO:0001508; P:action potential; IMP:MGI
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:MGI
GO:0048066; P:developmental pigmentation; IMP:MGI
GO:0042733; P:embryonic digit morphogenesis; IGI:MGI
GO:0021884; P:forebrain neuron development; IMP:MGI
GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:MGI
GO:0007215; P:glutamate receptor signaling pathway; IMP:MGI
GO:0007507; P:heart development; IMP:MGI
GO:0042711; P:maternal behavior; IMP:MGI
GO:0006469; P:negative regulation of protein kinase activity; IEA:Ensembl
GO:0016322; P:neuron remodeling; IMP:MGI
GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IGI:MGI
GO:0009791; P:post-embryonic development; IMP:MGI
GO:0050821; P:protein stabilization; IEA:Ensembl
GO:0035412; P:regulation of catenin import into nucleus; IEA:Ensembl
GO:0045634; P:regulation of melanocyte differentiation; IMP:MGI
GO:0001501; P:skeletal system development; IMP:MGI

Interpro

InterPro; IPR000654; Gprotein_alpha_Q
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00442; GPROTEINAQ;