LipidDB ID

LipidDB-10090-00441

Entry Name

UniProt Accession

P43006; O35877; O54686; O54687;

Theoretical PI

6.24

Molecular Weight

62030.21

Genbank Protein ID

AAA77673.1; BAA07854.1; AAA91643.1; AAB71737.1; AAB71738.1; BAA23770.1; BAA23771.1; BAA23772.1;

Genbank Nucleotide ID

U11763; D43796; U24699; U75372; U75373; AB007810; AB007811; AB007812;

Protein Name

Excitatory amino acid transporter 2

Protein Synonyms/Alias

GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2;

Gene Name

Slc1a2

Gene Synonyms/Alias

Eaat2; Glt1;

Created Date

01-NOV-1995

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Huang K, Kang MH, Askew C, Kang R, Sanders SS, Wan J, Davis NG, Hayden MR.Palmitoylation and function of glial glutamate transporter-1 is reduced in theYAC128 mouse model of Huntington disease. Neurobiol Dis. 2010 Oct;40(1):207-15.doi: 10.1016/j.nbd.2010.05.027. Epub 2010 Jun 2.[PMID:20685337]

Functional Description

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Sequence Annotation

Topological domain: 1 44 Cytoplasmic.
Transmembrane: 45 64 Helical.
Transmembrane: 88 108 Helical.
Transmembrane: 121 142 Helical.
Topological domain: 143 238 Extracellular.
Transmembrane: 239 258 Helical.
Transmembrane: 279 300 Helical.
Transmembrane: 316 338 Helical.
Transmembrane: 405 429 Helical.
Transmembrane: 436 458 Helical.
Modified residue: 537 537 Phosphotyrosine.

Protein Length

572 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0030673; C:axolemma; IDA:MGI
GO:0030424; C:axon; IDA:MGI
GO:0005887; C:integral component of plasma membrane; IC:MGI
GO:0015501; F:glutamate:sodium symporter activity; IDA:MGI
GO:0005313; F:L-glutamate transmembrane transporter activity; IMP:MGI
GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro
GO:0030534; P:adult behavior; IMP:MGI
GO:0031668; P:cellular response to extracellular stimulus; IMP:MGI
GO:0070779; P:D-aspartate import; IEA:Ensembl
GO:0051938; P:L-glutamate import; IEA:Ensembl
GO:0015813; P:L-glutamate transport; IDA:MGI
GO:0035264; P:multicellular organism growth; IMP:MGI
GO:0010259; P:multicellular organismal aging; IMP:MGI
GO:0007399; P:nervous system development; IMP:MGI
GO:0046326; P:positive regulation of glucose import; IMP:MGI
GO:0043200; P:response to amino acid; IMP:MGI
GO:0042493; P:response to drug; IMP:MGI
GO:0009416; P:response to light stimulus; IMP:MGI
GO:0009611; P:response to wounding; IMP:MGI
GO:0021537; P:telencephalon development; IMP:MGI
GO:0007632; P:visual behavior; IMP:MGI

Interpro

InterPro; IPR001991; Na-dicarboxylate_symporter
InterPro; IPR018107; Na-dicarboxylate_symporter_CS

Pfam

Pfam; PF00375; SDF;

SMART

PROSITE

PROSITE; PS00713; NA_DICARBOXYL_SYMP_1;
PROSITE; PS00714; NA_DICARBOXYL_SYMP_2;

PRINTS

PRINTS; PR00173; EDTRNSPORT;