Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00420
Entry Name
UniProt Accession
Theoretical PI
8.7
Molecular Weight
44462.98
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Prostacyclin receptor
Protein Synonyms/Alias
Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor;
Gene Name
Ptgir
Gene Synonyms/Alias
Created Date
01-NOV-1995
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
412
Canonical
KSEAIAACSLC****
[1]
S-Farnesylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Hayes JS, Lawler OA, Walsh MT, Kinsella BT. The prostacyclin receptor isisoprenylated. Isoprenylation is required for efficient receptor-effectorcoupling. J Biol Chem. 1999 Aug 20;274(34):23707-18.[PMID:10446129]
Functional Description
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Sequence Annotation
Topological domain: 1 44 Extracellular.
Transmembrane: 45 66 Helical; Name=1.
Topological domain: 67 79 Cytoplasmic.
Transmembrane: 80 104 Helical; Name=2.
Topological domain: 105 122 Extracellular.
Transmembrane: 123 143 Helical; Name=3.
Topological domain: 144 162 Cytoplasmic.
Transmembrane: 163 186 Helical; Name=4.
Topological domain: 187 215 Extracellular.
Transmembrane: 216 236 Helical; Name=5.
Topological domain: 237 263 Cytoplasmic.
Transmembrane: 264 288 Helical; Name=6.
Topological domain: 289 301 Extracellular.
Transmembrane: 302 322 Helical; Name=7.
Topological domain: 323 415 Cytoplasmic.
Modified residue: 412 412 Cysteine methyl ester.
Protein Length
415 AA.
Protein Sequence
(Canonical)
MMASDGHPGP PSVTPGSPLS AGGREWQGMA GSCWNITYVQ DSVGPATSTL MFVAGVVGNG  60
LALGILGARR RSHPSAFAVL VTGLAVTDLL GTCFLSPAVF VAYARNSSLL GLAHGGTMLC  120
DTFAFAMTFF GLASTLILFA MAVERCLALS HPYLYAQLDG PRCARFALPS IYAFCCLFCS  180
LPLLGLGEHQ QYCPGSWCFI RMRSAQPGGC AFSLAYASLM ALLVTSIFFC NGSVTLSLYH  240
MYRQQRRHHG SFVPTSRARE DEVYHLILLA LMTVIMAVCS LPLMIRGFTQ AIAPDSREMG  300
DLLAFRFNAF NPILDPWVFI LFRKAVFQRL KFWLCCLCAR SVHGDLQAPL SRPASGRRDP  360
PAPTSLQAKE GSWVPLSSWG TGQVAPLTAV PLTGGDGCSV GMPSKSEAIA ACSLC       415
FASTA
(Canonical)
>LipidDB-10090-00420|P43252
MMASDGHPGPPSVTPGSPLSAGGREWQGMAGSCWNITYVQDSVGPATSTLMFVAGVVGNG
LALGILGARRRSHPSAFAVLVTGLAVTDLLGTCFLSPAVFVAYARNSSLLGLAHGGTMLC
DTFAFAMTFFGLASTLILFAMAVERCLALSHPYLYAQLDGPRCARFALPSIYAFCCLFCS
LPLLGLGEHQQYCPGSWCFIRMRSAQPGGCAFSLAYASLMALLVTSIFFCNGSVTLSLYH
MYRQQRRHHGSFVPTSRAREDEVYHLILLALMTVIMAVCSLPLMIRGFTQAIAPDSREMG
DLLAFRFNAFNPILDPWVFILFRKAVFQRLKFWLCCLCARSVHGDLQAPLSRPASGRRDP
PAPTSLQAKEGSWVPLSSWGTGQVAPLTAVPLTGGDGCSVGMPSKSEAIAACSLC
Gene Ontology
GO:0005829; C:cytosol; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW
GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IMP:BHF-UCL
GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IMP:BHF-UCL
GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:BHF-UCL
GO:0030819; P:positive regulation of cAMP biosynthetic process; IMP:BHF-UCL
GO:0043950; P:positive regulation of cAMP-mediated signaling; IMP:BHF-UCL
GO:0032496; P:response to lipopolysaccharide; IMP:MGI
Interpro
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM
InterPro; IPR008365; Prostanoid_rcpt
InterPro; IPR000370; Prostglndn_IP_rcpt
Pfam
Pfam; PF00001; 7tm_1;
SMART
PROSITE
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;
PRINTS
PRINTS; PR01788; PROSTANOIDR;
PRINTS; PR00856; PRSTNOIDIPR;