Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00419
Entry Name
UniProt Accession
Theoretical PI
8.81
Molecular Weight
25243.05
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
T-cell-specific surface glycoprotein CD28
Protein Synonyms/Alias
CD28;
Gene Name
Cd28
Gene Synonyms/Alias
Created Date
01-JUL-1993
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
173
Canonical
LLVTVALCVIWTNSR
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Sequence Annotation
Topological domain: 20 150 Extracellular.
Transmembrane: 151 177 Helical.
Topological domain: 178 218 Cytoplasmic.
Domain: 29 138 Ig-like V-type.
Modified residue: 187 187 Phosphoserine.
Modified residue: 189 189 Phosphotyrosine.
Modified residue: 207 207 Phosphotyrosine.
Protein Length
218 AA.
Protein Sequence
(Canonical)
MTLRLLFLAL NFFSVQVTEN KILVKQSPLL VVDSNEVSLS CRYSYNLLAK EFRASLYKGV  60
NSDVEVCVGN GNFTYQPQFR SNAEFNCDGD FDNETVTFRL WNLHVNHTDI YFCKIEFMYP  120
PPYLDNERSN GTIIHIKEKH LCHTQSSPKL FWALVVVAGV LFCYGLLVTV ALCVIWTNSR  180
RNRLLQSDYM NMTPRRPGLT RKPYQPYAPA RDFAAYRP                          218
FASTA
(Canonical)
>LipidDB-10090-00419|P31041
MTLRLLFLALNFFSVQVTENKILVKQSPLLVVDSNEVSLSCRYSYNLLAKEFRASLYKGV
NSDVEVCVGNGNFTYQPQFRSNAEFNCDGDFDNETVTFRLWNLHVNHTDIYFCKIEFMYP
PPYLDNERSNGTIIHIKEKHLCHTQSSPKLFWALVVVAGVLFCYGLLVTVALCVIWTNSR
RNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP
Gene Ontology
GO:0009897; C:external side of plasma membrane; IDA:MGI
GO:0001772; C:immunological synapse; IDA:MGI
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0097190; P:apoptotic signaling pathway; IDA:MGI
GO:0006955; P:immune response; IEA:InterPro
GO:0045060; P:negative thymic T cell selection; IMP:MGI
GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IDA:MGI
GO:0002863; P:positive regulation of inflammatory response to antigenic stimulus; IMP:MGI
GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; ISS:UniProtKB
GO:0048304; P:positive regulation of isotype switching to IgG isotypes; IMP:MGI
GO:0045840; P:positive regulation of mitosis; ISS:UniProtKB
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:MGI
GO:0051897; P:positive regulation of protein kinase B signaling; IDA:MGI
GO:0042102; P:positive regulation of T cell proliferation; ISS:UniProtKB
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI
GO:0045066; P:regulatory T cell differentiation; IEA:Ensembl
GO:0031295; P:T cell costimulation; IDA:MGI
GO:0050852; P:T cell receptor signaling pathway; IMP:MGI
Interpro
InterPro; IPR008093; CD28
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
InterPro; IPR013106; Ig_V-set
Pfam
Pfam; PF07686; V-set;
SMART
SMART; SM00409; IG;
PROSITE
PRINTS
PRINTS; PR01717; CD28ANTIGEN;