| Tag |
Content |
LipidDB ID |
LipidDB-10090-00416 |
Entry Name |
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UniProt Accession |
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Theoretical PI |
5.72 |
Molecular Weight |
72196.7 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Amiloride-sensitive sodium channel subunit beta |
Protein Synonyms/Alias |
Beta-NaCH; Epithelial Na(+) channel subunit beta; Beta-ENaC; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; |
Gene Name |
Scnn1b |
Gene Synonyms/Alias |
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Created Date |
01-DEC-2000 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
43 | Canonical | HGPKRIICEGPKKKA | [1] | S-Palmitoylation | 557 | Canonical | IIKLVASCKGLRRRR | [1] | S-Palmitoylation |
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Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Mueller GM, Maarouf AB, Kinlough CL, Sheng N, Kashlan OB, Okumura S, Luthy S, Kleyman TR, Hughey RP. Cys palmitoylation of the beta subunit modulates gating ofthe epithelial sodium channel. J Biol Chem. 2010 Oct 1;285(40):30453-62. doi:10.1074/jbc.M110.151845. Epub 2010 Jul 27.[ PMID:20663869]
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Functional Description |
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus.Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
Sequence Annotation |
Topological domain: 1 51 Cytoplasmic.
Transmembrane: 52 75 Helical.
Topological domain: 76 512 Extracellular.
Transmembrane: 513 543 Helical.
Topological domain: 544 638 Cytoplasmic.
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Protein Length |
638 AA. |
Protein Sequence
(Canonical) |
MPVKKYLLKC LHRLQKGPGY TYKELLVWYC NNTNTHGPKR IICEGPKKKA MWFLLTLLFA 60
CLVCWQWGVF IQTYLSWEVS VSLSMGFKTM NFPAVTVCNS SPFQYSKVKH LLKDLDELME 120
AVLEKILAPE ASHSNTTRTL NFTIWNHTPL VLIDERNPDH PVVLNLFGDS HNSSNPAPGS 180
TCNAQGCKVA MRLCSANGTV CTLRNFTSAT QAVTEWYILQ ATNIFSQVLP QDLVGMGYAP 240
DRIILACLFG TEPCSHRNFT PIFYPDYGNC YIFNWGMTEE TLPSANPGTE FGLKLILDIG 300
QEDYVPFLAS TAGARLMLHE QRTYPFIREE GIYAMAGTET SIGVLVDKLQ RKGEPYSPCT 360
MNGSDVAIKN LYSVYNTTYS IQACLHSCFQ DHMIRNCSCG HYLYPLPEGE KYCNNRDFPD 420
WAYCYLNLQM SVTQRETCLS MCKESCNDTQ YKMTISMADW PSEASEDWIL HVLSQERDQS 480
SNITLSRKGI VKLNIYFQEF NYRTIEESPA NNIVWLLSNL GGQFGFWMGG SVLCLIEFGE 540
IIIDFIWITI IKLVASCKGL RRRRPQAPYT GPPPTVAELV EAHTNFGFQP DTTSCRPHGE 600
VYPDQQTLPI PGTPPPNYDS LRLQPLDTME SDSEVEAI 638
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FASTA
(Canonical) |
>LipidDB-10090-00416|Q9WU38
MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICEGPKKKAMWFLLTLLFA
CLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLDELME
AVLEKILAPEASHSNTTRTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGS
TCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAP
DRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGMTEETLPSANPGTEFGLKLILDIG
QEDYVPFLASTAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLVDKLQRKGEPYSPCT
MNGSDVAIKNLYSVYNTTYSIQACLHSCFQDHMIRNCSCGHYLYPLPEGEKYCNNRDFPD
WAYCYLNLQMSVTQRETCLSMCKESCNDTQYKMTISMADWPSEASEDWILHVLSQERDQS
SNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFGFWMGGSVLCLIEFGE
IIIDFIWITIIKLVASCKGLRRRRPQAPYTGPPPTVAELVEAHTNFGFQPDTTSCRPHGE
VYPDQQTLPIPGTPPPNYDSLRLQPLDTMESDSEVEAI
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Gene Ontology |
GO:0009897; C:external side of plasma membrane; IDA:MGI GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl GO:0016021; C:integral component of membrane; IDA:MGI GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB GO:0016020; C:membrane; IDA:MGI GO:0034706; C:sodium channel complex; IGI:MGI GO:0015280; F:ligand-gated sodium channel activity; IDA:MGI GO:0050699; F:WW domain binding; IPI:MGI GO:0050891; P:multicellular organismal water homeostasis; ISS:UniProtKB GO:0050896; P:response to stimulus; IEA:UniProtKB-KW GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW GO:0055078; P:sodium ion homeostasis; ISS:UniProtKB GO:0006814; P:sodium ion transport; IDA:MGI |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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