LipidDB ID

LipidDB-10090-00410

Entry Name

UniProt Accession

P70444; Q99M39;

Theoretical PI

4.69

Molecular Weight

21951.6

Genbank Protein ID

AAC71064.1; BAC32475.1; BAC34518.1; BAC34955.1; BAC36932.1; BAE36258.1; AAH02031.1;

Genbank Nucleotide ID

U75506; AK045731; AK051076; AK052356; AK077657; AK161235; BC002031;

Protein Name

BH3-interacting domain death agonist p11

Protein Synonyms/Alias

p22 BID; BID; p15 BID; p13 BID; p11 BID;

Gene Name

Bid

Gene Synonyms/Alias

Created Date

01-NOV-1997

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Maurer-Stroh S, Eisenhaber B, Eisenhaber F. N-terminal N-myristoylation ofproteins: prediction of substrate proteins from amino acid sequence. J Mol Biol. 2002 Apr 5;317(4):541-57.[PMID:11955008]
[2] Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ. PosttranslationalN-myristoylation of BID as a molecular switch for targeting mitochondria andapoptosis. Science. 2000 Dec 1;290(5497):1761-5.[PMID:11099414]

Functional Description

Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c.

Sequence Annotation

Motif: 87 100 BH3.
Functional site: 60 61 Cleavage.
Functional site: 75 76 Cleavage.
Functional site: 98 99 Cleavage.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 78 78 Phosphoserine.

Protein Length

195 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005737; C:cytoplasm; IDA:MGI
GO:0005829; C:cytosol; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0032592; C:integral component of mitochondrial membrane; IDA:BHF-UCL
GO:0016020; C:membrane; IDA:MGI
GO:0005739; C:mitochondrion; IDA:MGI
GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI
GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI
GO:0007420; P:brain development; IEA:Ensembl
GO:0090150; P:establishment of protein localization to membrane; IEA:Ensembl
GO:0097191; P:extrinsic apoptotic signaling pathway; IMP:MGI
GO:0034349; P:glial cell apoptotic process; IEA:Ensembl
GO:0097284; P:hepatocyte apoptotic process; IGI:MGI
GO:0097345; P:mitochondrial outer membrane permeabilization; IGI:MGI
GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl
GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl
GO:0032464; P:positive regulation of protein homooligomerization; IDA:BHF-UCL
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IGI:BHF-UCL
GO:0051260; P:protein homooligomerization; IDA:BHF-UCL
GO:0006626; P:protein targeting to mitochondrion; IMP:MGI
GO:0042127; P:regulation of cell proliferation; IMP:MGI
GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:MGI
GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IGI:MGI
GO:0032459; P:regulation of protein oligomerization; IDA:UniProtKB
GO:0001836; P:release of cytochrome c from mitochondria; IDA:MGI
GO:0032355; P:response to estradiol; IEA:Ensembl
GO:0042770; P:signal transduction in response to DNA damage; TAS:UniProtKB

Interpro

InterPro; IPR020728; Bcl2_BH3_motif_CS
InterPro; IPR010479; BID

Pfam

Pfam; PF06393; BID;

SMART

PROSITE

PROSITE; PS01259; BH3;

PRINTS