Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00407
Entry Name
UniProt Accession
Theoretical PI
7.43
Molecular Weight
74635.43
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Amiloride-sensitive sodium channel subunit gamma
Protein Synonyms/Alias
Epithelial Na(+) channel subunit gamma; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG;
Gene Name
Scnn1g
Gene Synonyms/Alias
Created Date
01-DEC-2000
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
33
Canonical
KDLMHWYCLNTNTHG
[1]
S-Palmitoylation
41
Canonical
LNTNTHGCRRIVVSR
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Mukherjee A, Mueller GM, Kinlough CL, Sheng N, Wang Z, Mustafa SA, Kashlan OB,Kleyman TR, Hughey RP. Cysteine palmitoylation of the γ subunit has a dominantrole in modulating activity of the epithelial sodium channel. J Biol Chem. 2014May 16;289(20):14351-9. doi: 10.1074/jbc.M113.526020. Epub 2014 Apr 1. PubMedPMID: 24692558; PubMed Central PMCID: PMC4022901.[PMID:24692558]
Functional Description
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Sequence Annotation
Topological domain: 1 55 Cytoplasmic.
Transmembrane: 56 79 Helical.
Topological domain: 80 529 Extracellular.
Transmembrane: 530 561 Helical.
Topological domain: 562 655 Cytoplasmic.
Protein Length
655 AA.
Protein Sequence
(Canonical)
MAPGEKIKAK IKKNLPVRGP QAPTIKDLMH WYCLNTNTHG CRRIVVSRGR LRRLLWIAFT  60
LTAVALIIWQ CALLVFSFYT VSVSIKVHFQ KLDFPAVTIC NINPYKYSAV SDLLTDLDSE  120
TKQALLSLYG VKDVLDSTPR KRREAGSMRS TWEGTPPRFL NLIPLLVFNE NEKGKARDFF  180
TGRKRKISGK IIHKASNVMH VHESKKLVGF QLCSNDTSDC ATYTFSSGIN AIQEWYKLHY  240
MNIMAQVPLE KKINMSYSAE ELLVTCFFDG MSCDARNFTL FHHPMYGNCY TFNNRENATI  300
LSTSMGGSEY GLQVILYINE DEYNPFLVSS TGAKVLVHQQ NEYPFIEDVG TEIETAMSTS  360
IGMHLTESFK LSEPYSQCTE DGSDVPVTNI YNAAYSLQIC LYSCFQTKMV EKCGCAQYSQ  420
PLPPAANYCN YQQHPNWMYC YYQLYQAFVR EELGCQSVCK QSCSFKEWTL TTSLAQWPSE  480
ASEKWLLNVL TWDQSQQINK KLNKTDLAKL LIFYKDLNQR SIMESPANSI EMLLSNFGGQ  540
LGLWMSCSVV CVIEIIEVFF IDFFSIIARR QWQKAKDWWA RRRTPPSTET PSSQQGQDNP  600
ALDTDDDLPT FTSAMRLPPA PEAPVPGTPP PRYNTLRLDS AFSSQLTDTQ LTNEF       655
FASTA
(Canonical)
>LipidDB-10090-00407|Q9WU39
MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRIVVSRGRLRRLLWIAFT
LTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNINPYKYSAVSDLLTDLDSE
TKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNENEKGKARDFF
TGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHY
MNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNRENATI
LSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAKVLVHQQNEYPFIEDVGTEIETAMSTS
IGMHLTESFKLSEPYSQCTEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVEKCGCAQYSQ
PLPPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTLTTSLAQWPSE
ASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQ
LGLWMSCSVVCVIEIIEVFFIDFFSIIARRQWQKAKDWWARRRTPPSTETPSSQQGQDNP
ALDTDDDLPTFTSAMRLPPAPEAPVPGTPPPRYNTLRLDSAFSSQLTDTQLTNEF
Gene Ontology
GO:0009897; C:external side of plasma membrane; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016021; C:integral component of membrane; IDA:MGI
GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB
GO:0016020; C:membrane; IDA:MGI
GO:0034706; C:sodium channel complex; IGI:MGI
GO:0015280; F:ligand-gated sodium channel activity; IDA:MGI
GO:0050699; F:WW domain binding; IPI:MGI
GO:0050891; P:multicellular organismal water homeostasis; ISS:UniProtKB
GO:0050896; P:response to stimulus; IEA:UniProtKB-KW
GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW
GO:0055078; P:sodium ion homeostasis; ISS:UniProtKB
GO:0006814; P:sodium ion transport; IDA:MGI
Interpro
InterPro; IPR004724; EnaC
InterPro; IPR001873; Na+channel_ASC
InterPro; IPR020903; Na+channel_ASC_CS
Pfam
Pfam; PF00858; ASC;
SMART
PROSITE
PROSITE; PS01206; ASC;
PRINTS
PRINTS; PR01078; AMINACHANNEL;