LipidDB ID

LipidDB-10090-00401

Entry Name

UniProt Accession

Q61411; F7BIB2; Q6P716; Q80WD2; Q811B9;

Theoretical PI

5.16

Molecular Weight

21298.13

Genbank Protein ID

CAA90306.1; AAQ81319.1; EDL18008.1; EDL18009.1; AAH61885.1; AAP21090.1; CAD24593.1;

Genbank Nucleotide ID

Z50013; AY373386; AC108908; CH466531; CH466531; BC061885; S74119; AJ437023;

Protein Name

GTPase HRas, N-terminally processed

Protein Synonyms/Alias

H-Ras-1; Transforming protein p21; c-H-ras; p21ras;

Gene Name

Hras

Gene Synonyms/Alias

Hras1;

Created Date

01-NOV-1997

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid
[2] Khan SG, Bickers DR, Mukhtar H, Agarwal R. Ras p21 farnesylation inultraviolet B radiation-induced tumors in the skin of SKH-1 hairless mice. JInvest Dermatol. 1994 May;102(5):754-8.[PMID:8176259]

Functional Description

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Sequence Annotation

Nucleotide-binding: 10 17 GTP.
Nucleotide-binding: 57 61 GTP.
Nucleotide-binding: 116 119 GTP.
Region: 166 185 Hypervariable region.
Motif: 32 40 Effector region.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 2 2 N-acetylthreonine; in GTPase HRas, N-terminally processed.
Modified residue: 118 118 S-nitrosocysteine.
Modified residue: 186 186 Cysteine methyl ester.

Protein Length

189 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005794; C:Golgi apparatus; ISS:UniProtKB
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0005525; F:GTP binding; IDA:MGI
GO:0007569; P:cell aging; IDA:MGI
GO:0007050; P:cell cycle arrest; IEA:Ensembl
GO:0008283; P:cell proliferation; IPI:MGI
GO:0090398; P:cellular senescence; IEA:Ensembl
GO:0006897; P:endocytosis; IDA:MGI
GO:0006184; P:GTP catabolic process; IEA:InterPro
GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:MGI
GO:0007093; P:mitotic cell cycle checkpoint; IEA:Ensembl
GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl
GO:0010629; P:negative regulation of gene expression; IEA:Ensembl
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:MGI
GO:0034259; P:negative regulation of Rho GTPase activity; IEA:Ensembl
GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl
GO:0030335; P:positive regulation of cell migration; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IDA:MGI
GO:0045740; P:positive regulation of DNA replication; IEA:Ensembl
GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl
GO:0010628; P:positive regulation of gene expression; IDA:MGI
GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl
GO:0043406; P:positive regulation of MAP kinase activity; IEA:Ensembl
GO:2000630; P:positive regulation of miRNA metabolic process; IEA:Ensembl
GO:0032855; P:positive regulation of Rac GTPase activity; IEA:Ensembl
GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:MGI
GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Ensembl
GO:0090303; P:positive regulation of wound healing; IEA:Ensembl
GO:0051291; P:protein heterooligomerization; IEA:Ensembl
GO:0007265; P:Ras protein signal transduction; TAS:MGI
GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI
GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI
GO:0035176; P:social behavior; IEA:Ensembl

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;