Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00397
Entry Name
UniProt Accession
Theoretical PI
5.82
Molecular Weight
24408.7
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Ras-related protein Rab-4A
Protein Synonyms/Alias
Gene Name
Rab4a
Gene Synonyms/Alias
Rab4;
Created Date
15-JUL-1998
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
216
Canonical
QAPSAQECGC*****
[1]
S-Geranylgeranylation
218
Canonical
PSAQECGC*******
[1]
S-Geranylgeranylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Goalstone ML, Leitner JW, Golovchenko I, Stjernholm MR, Cormont M, LeMarchand-Brustel Y, Draznin B. Insulin promotes phosphorylation and activation ofgeranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 andrab-4. J Biol Chem. 1999 Jan 29;274(5):2880-4.[PMID:9915824]
Functional Description
Protein transport. Probably involved in vesicular traffic (By similarity).
Sequence Annotation
Nucleotide-binding: 20 28 GTP.
Nucleotide-binding: 68 72 GTP.
Nucleotide-binding: 126 129 GTP.
Nucleotide-binding: 156 158 GTP.
Motif: 42 50 Effector region.
Modified residue: 204 204 Phosphoserine; by CDK1.
Modified residue: 218 218 Cysteine methyl ester.
Protein Length
218 AA.
Protein Sequence
(Canonical)
MAQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF GSKIINVGGK  60
YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET YNALTNWLTD ARMLASQNIV  120
LILCGNKKDL DADREVTFLE ASRFAQENEL MFLETSALTG ENVEEAFMQC ARKILNKIES  180
GELDPERMGS GIQYGDAALR QLRSPRRTQA PSAQECGC                          218
FASTA
(Canonical)
>LipidDB-10090-00397|P56371
MAQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGK
YVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIV
LILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFMQCARKILNKIES
GELDPERMGSGIQYGDAALRQLRSPRRTQAPSAQECGC
Gene Ontology
GO:0005737; C:cytoplasm; IDA:MGI
GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome
GO:0005768; C:endosome; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0019003; F:GDP binding; ISS:UniProtKB
GO:0005525; F:GTP binding; ISS:UniProtKB
GO:0003924; F:GTPase activity; ISS:UniProtKB
GO:0008565; F:protein transporter activity; IDA:MGI
GO:0019882; P:antigen processing and presentation; IEA:Ensembl
GO:0015031; P:protein transport; IDA:MGI
GO:0030100; P:regulation of endocytosis; IDA:MGI
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro
Interpro
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR003579; Small_GTPase_Rab_type
Pfam
Pfam; PF00071; Ras;
SMART
SMART; SM00175; RAB;
PROSITE
PROSITE; PS51419; RAB;
PRINTS
PRINTS; PR00449; RASTRNSFRMNG;