| Tag |
Content |
LipidDB ID |
LipidDB-10090-00389 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.14 |
Molecular Weight |
58482.98 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Neutral amino acid transporter B(0) |
Protein Synonyms/Alias |
ATB(0); ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Insulin-activated amino acid transporter; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5; |
Gene Name |
Slc1a5 |
Gene Synonyms/Alias |
Aaat; Asct2; Slc1a7; |
Created Date |
01-OCT-1996 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
172 | Canonical | NDSVVDPCARSAPTK | [1] | S-Palmitoylation | 320 | Canonical | SLGKYILCCLLGHAI | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. |
Sequence Annotation |
Topological domain: 1 51 Cytoplasmic.
Transmembrane: 52 72 Helical.
Transmembrane: 98 118 Helical.
Transmembrane: 132 152 Helical.
Topological domain: 153 236 Extracellular.
Transmembrane: 237 257 Helical.
Transmembrane: 278 298 Helical.
Transmembrane: 318 338 Helical.
Transmembrane: 348 368 Helical.
Transmembrane: 389 409 Helical.
Transmembrane: 411 431 Helical.
Transmembrane: 438 458 Helical.
Modified residue: 1 1 N-acetylmethionine.
Modified residue: 505 505 Phosphoserine.
Modified residue: 506 506 Phosphoserine.
Modified residue: 518 518 Phosphoserine.
|
Protein Length |
553 AA. |
Protein Sequence
(Canonical) |
MAVDPPKADP KGVAVDSSRR CPALGSREDQ SAKAGGCCGS RDRVRRCIRA NLLVLLTVAA 60
VVAGVGLGLG VSAAGGADAL GPARLTRFAF PGELLLRLLK MIILPLVVCS LIGGAASLDP 120
SALGRVGAWA LLFFLVTTLL ASALGVGLAL ALKPGAAVTA ITSINDSVVD PCARSAPTKE 180
ALDSFLDLVR NIFPSNLVSA AFRSFATSYE PKDNSCKIPQ SCIQREINST MVQLLCEVEG 240
MNILGLVVFA IVFGVALRKL GPEGELLIRF FNSFNDATMV LVSWIMWYAP VGILFLVASK 300
IVEMKDVRQL FISLGKYILC CLLGHAIHGL LVLPLIYFLF TRKNPYRFLW GIMTPLATAF 360
GTSSSSATLP LMMKCVEEKN GVAKHISRFI LPIGATVNMD GAALFQCVAA VFIAQLNGVS 420
LDFVKIITIL VTATASSVGA AGIPAGGVLT LAIILEAVSL PVKDISLILA VDWLVDRSCT 480
VLNVEGDAFG AGLLQSYVDR TKMPSSEPEL IQVKNEVSLN PLPLATEEGN PLLKQYQGPT 540
GDSSATFEKE SVM 553
|
FASTA
(Canonical) |
>LipidDB-10090-00389|P51912
MAVDPPKADPKGVAVDSSRRCPALGSREDQSAKAGGCCGSRDRVRRCIRANLLVLLTVAA
VVAGVGLGLGVSAAGGADALGPARLTRFAFPGELLLRLLKMIILPLVVCSLIGGAASLDP
SALGRVGAWALLFFLVTTLLASALGVGLALALKPGAAVTAITSINDSVVDPCARSAPTKE
ALDSFLDLVRNIFPSNLVSAAFRSFATSYEPKDNSCKIPQSCIQREINSTMVQLLCEVEG
MNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPVGILFLVASK
IVEMKDVRQLFISLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIMTPLATAF
GTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGVS
LDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAVSLPVKDISLILAVDWLVDRSCT
VLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNEVSLNPLPLATEEGNPLLKQYQGPT
GDSSATFEKESVM
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; ISS:UniProtKB GO:0015175; F:neutral amino acid transmembrane transporter activity; IDA:MGI GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:InterPro GO:0015804; P:neutral amino acid transport; IDA:GOC |
Interpro |
InterPro; IPR001991; Na-dicarboxylate_symporter InterPro; IPR018107; Na-dicarboxylate_symporter_CS |
Pfam |
|
SMART |
|
PROSITE |
PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; |
PRINTS |
|