Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00343
Entry Name
UniProt Accession
Theoretical PI
5.38
Molecular Weight
135074.47
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Processed neural cell adhesion molecule L1-like protein
Protein Synonyms/Alias
Cell adhesion molecule with homology to L1CAM; Chl1-like protein; Close homolog of L1;
Gene Name
Chl1
Gene Synonyms/Alias
Call;
Created Date
25-JUL-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
1102
Canonical
TLILLTICFVKRNRG
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Tian N, Leshchyns'ka I, Welch JH, Diakowski W, Yang H, Schachner M, Sytnyk V. Lipid raft-dependent endocytosis of close homolog of adhesion molecule L1 (CHL1) promotes neuritogenesis. J Biol Chem. 2012 Dec 28;287(53):44447-63. doi:10.1074/jbc.M112.394973. Epub 2012 Nov 9.[PMID:23144456]
Functional Description
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.
Sequence Annotation
Topological domain: 26 1083 Extracellular.
Transmembrane: 1084 1104 Helical.
Topological domain: 1105 1209 Cytoplasmic.
Domain: 35 124 Ig-like C2-type 1.
Domain: 128 223 Ig-like C2-type 2.
Domain: 235 328 Ig-like C2-type 3.
Domain: 331 417 Ig-like C2-type 4.
Domain: 423 510 Ig-like C2-type 5.
Domain: 515 607 Ig-like C2-type 6.
Domain: 614 709 Fibronectin type-III 1.
Domain: 714 807 Fibronectin type-III 2.
Domain: 812 914 Fibronectin type-III 3.
Domain: 918 1015 Fibronectin type-III 4.
Motif: 555 558 DGEA.
Motif: 1182 1186 FIG[AQ]Y.
Functional site: 753 754 Cleavage; by ADAM8.
Functional site: 1040 1041 Cleavage; by ADAM8.
Protein Length
1209 AA.
Protein Sequence
(Canonical)
MMELPLCGRG LILSLIFLLL KLSAAEIPLS VQQVPTIVKQ SYVQVAFPFD EYFQIECEAK  60
GNPEPIFSWT KDDKPFDLSD PRIIAANNSG TFKIPNEGHI SHFQGKYRCF ASNRLGTAVS  120
EEIEFIVPGV PKFPKEKIEP IDVEEGDSIV LPCNPPKGLP PLHIYWMNIE LEHIEQDERV  180
YMSQRGDLYF ANVEENDSRN DYCCFAAFPK LRTIVQKMPM KLTVNSSNSI KQRKPKLLLP  240
PAQMGSLSAK TVLKGDTLLL ECFAEGLPTP HIQWSKPGSE LPEGRATIEV HEKTLKIENI  300
SYQDRGNYRC TANNLLGKAS HDFHVTVEEP PRWKKKPQSA VYSTGSSGIL LCEAEGEPQP  360
TIKWRLNGLP IEKHPFPGDF MFPREISFTN LLPNHTGVYQ CEASNIHGTI LANANIDVID  420
VIPLIKTKNE ENYATVVGYS AFLHCEYFAS PKATVVWEVA DETHPLEGDR YHTHENGTLE  480
IYRTTEEDAG SYSCWVDNAM GKAVITANLD IRNATKLRVS PKNPRIPKSH VLELYCESQC  540
DSHLKHSLKL SWSKDGEAFE MNGTEDGRIV IDGAYLTISN ITAEDQGVYS CSAQTSLDST  600
SEKTQVTVLG VPDPPGNLHL SERQNRSVRL SWEAGDDHNS KISEYIVEFE GNREEPGKWE  660
ELTRVQGEET DVVLSLAPYV RYQFRVTAVN EVGRSHASLP SDHHETPPAA PDKNPQNIRV  720
QASQPKEMII KWEPLKSMEQ NGPGLEYKVS WKPQGAPEEW EEEIVTNHTL RVMTPTVYAP  780
YDVKVQAINQ LGSSPDPQPV TLYSGEDYPS TAPVIQRVDV MNSTLVKVTW SSIPKETVHG  840
LLRGYQINWW KTKSLLDGRT HPKEVNILRF SGQRNSGMVP SLDPFSEFHL TVLAYNSKGA  900
GPESEPYIFQ TPEGVPEQPS FLKVIKVDKD TATLSWGLPK KLNGNLTGYL LQYQIINDTY  960
ELGELNEINV TTPSKSSWHL SNLNSTTKYK FYLRACTSRG CGKPISEEGA TLGEGSKGIR  1020
KITEGVNVTQ KIHPVEVLVP GAEHIVHLMT KNWGDNDSIF QDVIETRGRE YAGLYDDIST  1080
QGWFIGLMCA IALLTLILLT ICFVKRNRGG KYSVKEKEDL HPDPEVQSAK DETFGEYSDS  1140
DEKPLKGSLR SLNRNMQPTE SADSLVEYGE GDQSIFNEDG SFIGAYTGAK EKGSVESNGS  1200
STATFPLRA                                                          1209
FASTA
(Canonical)
>LipidDB-10090-00343|P70232
MMELPLCGRGLILSLIFLLLKLSAAEIPLSVQQVPTIVKQSYVQVAFPFDEYFQIECEAK
GNPEPIFSWTKDDKPFDLSDPRIIAANNSGTFKIPNEGHISHFQGKYRCFASNRLGTAVS
EEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGLPPLHIYWMNIELEHIEQDERV
YMSQRGDLYFANVEENDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSSNSIKQRKPKLLLP
PAQMGSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSELPEGRATIEVHEKTLKIENI
SYQDRGNYRCTANNLLGKASHDFHVTVEEPPRWKKKPQSAVYSTGSSGILLCEAEGEPQP
TIKWRLNGLPIEKHPFPGDFMFPREISFTNLLPNHTGVYQCEASNIHGTILANANIDVID
VIPLIKTKNEENYATVVGYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLE
IYRTTEEDAGSYSCWVDNAMGKAVITANLDIRNATKLRVSPKNPRIPKSHVLELYCESQC
DSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDST
SEKTQVTVLGVPDPPGNLHLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWE
ELTRVQGEETDVVLSLAPYVRYQFRVTAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRV
QASQPKEMIIKWEPLKSMEQNGPGLEYKVSWKPQGAPEEWEEEIVTNHTLRVMTPTVYAP
YDVKVQAINQLGSSPDPQPVTLYSGEDYPSTAPVIQRVDVMNSTLVKVTWSSIPKETVHG
LLRGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDPFSEFHLTVLAYNSKGA
GPESEPYIFQTPEGVPEQPSFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTY
ELGELNEINVTTPSKSSWHLSNLNSTTKYKFYLRACTSRGCGKPISEEGATLGEGSKGIR
KITEGVNVTQKIHPVEVLVPGAEHIVHLMTKNWGDNDSIFQDVIETRGREYAGLYDDIST
QGWFIGLMCAIALLTLILLTICFVKRNRGGKYSVKEKEDLHPDPEVQSAKDETFGEYSDS
DEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEKGSVESNGS
STATFPLRA
Gene Ontology
GO:0045177; C:apical part of cell; IDA:MGI
GO:0030425; C:dendrite; IDA:MGI
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; TAS:Reactome
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-KW
GO:0002020; F:protease binding; IPI:BHF-UCL
GO:0008344; P:adult locomotory behavior; IMP:MGI
GO:0007411; P:axon guidance; IMP:MGI
GO:0031103; P:axon regeneration; IEA:Ensembl
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW
GO:0050890; P:cognition; IMP:MGI
GO:0035640; P:exploration behavior; IMP:MGI
GO:0043524; P:negative regulation of neuron apoptotic process; IDA:BHF-UCL
GO:0001764; P:neuron migration; IMP:MGI
GO:0031175; P:neuron projection development; IDA:MGI
Interpro
InterPro; IPR003961; Fibronectin_type3
InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR013098; Ig_I-set
InterPro; IPR003599; Ig_sub
InterPro; IPR003598; Ig_sub2
InterPro; IPR026966; Neurofascin/L1/NrCAM_C
Pfam
Pfam; PF13882; Bravo_FIGEY;
Pfam; PF00041; fn3;
Pfam; PF07679; I-set;
SMART
SMART; SM00060; FN3;
SMART; SM00409; IG;
SMART; SM00408; IGc2;
PROSITE
PROSITE; PS50853; FN3;
PROSITE; PS50835; IG_LIKE;
PRINTS