| Tag |
Content |
LipidDB ID |
LipidDB-10090-00342 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
9.12 |
Molecular Weight |
42336.96 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Podocin |
Protein Synonyms/Alias |
|
Gene Name |
Nphs2 |
Gene Synonyms/Alias |
|
Created Date |
23-APR-2003 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
126 | Canonical | FPFSIWFCIKVVQEY | [1] | S-Palmitoylation | 160 | Canonical | GLFFFLPCLDTYHKV | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Huber TB, Schermer B, Müller RU, Höhne M, Bartram M, Calixto A, Hagmann H,Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, SimonsM, Pavenstädt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T. Podocinand MEC-2 bind cholesterol to regulate the activity of associated ion channels.Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17079-86. Epub 2006 Nov 1. PubMedPMID: 17079490; PubMed Central PMCID: PMC1859892.[ PMID:17079490]
|
Functional Description |
Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. |
Sequence Annotation |
Topological domain: 1 104 Cytoplasmic.
Transmembrane: 105 125 Helical.
Topological domain: 126 385 Extracellular.
|
Protein Length |
385 AA. |
Protein Sequence
(Canonical) |
MDSRARSSSR EAHGRSSRSS SRDDKKAKAG RGSRGRARPD AGAERQSTGR TATRGEPRAP 60
AATATVVDVD EVRGPGEEGT EVVALLESER PEEGIKPSGL GACEWLLVLA SLIFIIMTFP 120
FSIWFCIKVV QEYERVIIFR LGHLLPGRAK GPGLFFFLPC LDTYHKVDLR LQTLEIPFHE 180
VVTKDMFIME IDAVCYYRME NASLLLSSLA HVSKAIQFLV QTTMKRLLAH RSLTEILLER 240
KSIAQDVKVA LDAVTCIWGI KVERTEIKDV RLPAGLQHSL AVEAEAQRQA KVRVIAAEGE 300
KAASESLRMA AEILSGTPAA VQLRYLHTLQ SLSTEKPATV VLPLPFDMLS LLSSPGNRAQ 360
GSINYPSSSK PVEPLNPKKK DSPML 385
|
FASTA
(Canonical) |
>LipidDB-10090-00342|Q91X05
MDSRARSSSREAHGRSSRSSSRDDKKAKAGRGSRGRARPDAGAERQSTGRTATRGEPRAP
AATATVVDVDEVRGPGEEGTEVVALLESERPEEGIKPSGLGACEWLLVLASLIFIIMTFP
FSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHE
VVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSLTEILLER
KSIAQDVKVALDAVTCIWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAEGE
KAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPATVVLPLPFDMLSLLSSPGNRAQ
GSINYPSSSKPVEPLNPKKKDSPML
|
Gene Ontology |
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl GO:0005887; C:integral component of plasma membrane; IEA:InterPro GO:0031235; C:intrinsic component of the cytoplasmic side of the plasma membrane; IDA:UniProtKB GO:0045121; C:membrane raft; IEA:Ensembl GO:0005886; C:plasma membrane; IDA:MGI GO:0043234; C:protein complex; IEA:Ensembl GO:0036057; C:slit diaphragm; IEA:Ensembl GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl GO:0007588; P:excretion; IEA:InterPro GO:0072249; P:metanephric glomerular visceral epithelial cell development; IEA:Ensembl |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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