| Tag |
Content |
LipidDB ID |
LipidDB-10090-00337 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.36 |
Molecular Weight |
99530.1 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha |
Protein Synonyms/Alias |
GMP-PDE alpha; 3.1.4.35; |
Gene Name |
Pde6a |
Gene Synonyms/Alias |
Mpa; Pdea; |
Created Date |
01-AUG-1992 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
856 | Canonical | GAPASKSCCIQ**** | [1] | S-Farnesylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Qin N, Pittler SJ, Baehr W. In vitro isoprenylation and membrane associationof mouse rod photoreceptor cGMP phosphodiesterase alpha and beta subunitsexpressed in bacteria. J Biol Chem. 1992 Apr 25;267(12):8458-63.[ PMID:1314827]
|
Functional Description |
This protein participates in processes of transmission and amplification of the visual signal. |
Sequence Annotation |
Domain: 73 222 GAF 1.
Domain: 254 431 GAF 2.
Active site: 559 559 Proton donor.
Metal binding site: 563 563 Divalent metal cation 1.
Metal binding site: 599 599 Divalent metal cation 1.
Metal binding site: 600 600 Divalent metal cation 1.
Metal binding site: 600 600 Divalent metal cation 2.
Metal binding site: 720 720 Divalent metal cation 1.
Modified residue: 2 2 N-acetylglycine.
Modified residue: 856 856 Cysteine methyl ester.
|
Protein Length |
859 AA. |
Protein Sequence
(Canonical) |
MGEVTAEEVE KFLDSNIGFA KQYYNFHYRG KVISDLLGAK EAAVDFSNYH DVNSVEESEI 60
IFDLLRDVQE NLQAEKCTFN VMKKLCFLLR ADRMSLFMYR TRNGIAELAT RLFNVHKDAV 120
LEDCLVMPDS EIVFPLDMGV VGHVAHSKKI ANVPNTEEDE HFCDFVDNLT EYQTKNILAS 180
PIMNGKDVVA IIMAVNKIDE PHFTKRDEEI LLKYLNFVNL IMKVFHLSYL HNCETRRGQI 240
LLWSGSKVFE ELTDIERQFH KALYTVRAFL NCDRYSVGLL DMTKQKEFFD VWPVLMGEAP 300
AYSGPRTPDG REINFYKVID YILHGKEDIK VIPNPPADHW ALVSGLPTYV AQNGLICNIM 360
NAPAEDFFEF QKEPLDESGW MIKNVLSMPI VNKKEEIVGV ATFYNRKDGK PFDDMDETLM 420
ESLTQFLGWS VLNPDTYESM NKLENRKDIF QDIVKYHVKC DNEEIQKILK TREVYGKEPW 480
ECEEEELAEI LQGELPDAES YEINKFHFSD LPLTELELVK CGIQMYYELR VVDKFHIPQE 540
ALVRFMYSLS KGYRRITYHN WRHGFNVGQT MFSLLVTGKL KRYFTDLEAL AMVTAAFCHD 600
IDHRGTNNLY QMKSQNPLAK LHGSSILERH HLEFGKTLLR DESLNIFQNL NRRQHEHAIH 660
MMDIAIIATD LALYFKKRTM FQKIVDQSKT YESTQEWTQY MMLEQTRKEI VMAMMMTACD 720
LSAITKPWEV QSKVALLVAA EFWEQGDLER TVLQQNPIPM MDRNKADELP KLQVGFIDFV 780
CTFVYKEFSR FHEEITPMLD GITNNRKEWK ALADEYEAKM KALEEEKQKQ QAAKQAASGN 840
QPGGNPLQGA PASKSCCIQ 859
|
FASTA
(Canonical) |
>LipidDB-10090-00337|P27664
MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVISDLLGAKEAAVDFSNYHDVNSVEESEI
IFDLLRDVQENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTRNGIAELATRLFNVHKDAV
LEDCLVMPDSEIVFPLDMGVVGHVAHSKKIANVPNTEEDEHFCDFVDNLTEYQTKNILAS
PIMNGKDVVAIIMAVNKIDEPHFTKRDEEILLKYLNFVNLIMKVFHLSYLHNCETRRGQI
LLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAP
AYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPADHWALVSGLPTYVAQNGLICNIM
NAPAEDFFEFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDMDETLM
ESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPW
ECEEEELAEILQGELPDAESYEINKFHFSDLPLTELELVKCGIQMYYELRVVDKFHIPQE
ALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHD
IDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIH
MMDIAIIATDLALYFKKRTMFQKIVDQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTACD
LSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFV
CTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYEAKMKALEEEKQKQQAAKQAASGN
QPGGNPLQGAPASKSCCIQ
|
Gene Ontology |
GO:0005886; C:plasma membrane; TAS:Reactome GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:UniProtKB-EC GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO:0060041; P:retina development in camera-type eye; IMP:MGI GO:0007165; P:signal transduction; IEA:InterPro GO:0007601; P:visual perception; IEA:UniProtKB-KW |
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
|
PRINTS |
|