LipidDB ID

LipidDB-10090-00312

Entry Name

UniProt Accession

Q8QZT1; Q3TE92;

Theoretical PI

8.71

Molecular Weight

44816.12

Genbank Protein ID

CAD52869.1; BAC27697.1; BAC38304.1; BAE41356.1; AAH24763.1;

Genbank Nucleotide ID

AJ510150; AK032097; AK081715; AK169771; BC024763;

Protein Name

Acetyl-CoA acetyltransferase, mitochondrial

Protein Synonyms/Alias

2.3.1.9; Acetoacetyl-CoA thiolase;

Gene Name

Acat1

Gene Synonyms/Alias

Created Date

13-SEP-2004

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Plays a major role in ketone body metabolism.

Sequence Annotation

Region: 255 257 Coenzyme A binding.
Active site: 123 123 Acyl-thioester intermediate.
Active site: 382 382 Proton acceptor.
Active site: 410 410 Proton acceptor.
Metal binding site: 216 216 Potassium.
Metal binding site: 277 277 Potassium; via carbonyl oxygen.
Metal binding site: 278 278 Potassium; via carbonyl oxygen.
Metal binding site: 280 280 Potassium; via carbonyl oxygen.
Metal binding site: 378 378 Potassium; via carbonyl oxygen.
Binding site: 216 216 Coenzyme A.
Binding site: 260 260 Coenzyme A.
Binding site: 281 281 Coenzyme A.
Modified residue: 63 63 N6-acetyllysine; alternate.
Modified residue: 63 63 N6-succinyllysine; alternate.
Modified residue: 75 75 N6-succinyllysine.
Modified residue: 171 171 N6-acetyllysine; alternate.
Modified residue: 171 171 N6-succinyllysine; alternate.
Modified residue: 178 178 N6-acetyllysine; alternate.
Modified residue: 178 178 N6-succinyllysine; alternate.
Modified residue: 187 187 N6-acetyllysine; alternate.
Modified residue: 187 187 N6-succinyllysine; alternate.
Modified residue: 199 199 N6-acetyllysine; alternate.
Modified residue: 199 199 N6-succinyllysine; alternate.
Modified residue: 220 220 N6-acetyllysine; alternate.
Modified residue: 220 220 N6-succinyllysine; alternate.
Modified residue: 227 227 N6-acetyllysine; alternate.
Modified residue: 227 227 N6-succinyllysine; alternate.
Modified residue: 240 240 N6-succinyllysine.
Modified residue: 242 242 N6-acetyllysine; alternate.
Modified residue: 242 242 N6-succinyllysine; alternate.
Modified residue: 248 248 N6-acetyllysine.
Modified residue: 254 254 N6-acetyllysine.
Modified residue: 260 260 N6-acetyllysine; alternate.
Modified residue: 260 260 N6-succinyllysine; alternate.
Modified residue: 263 263 N6-succinyllysine.
Modified residue: 265 265 N6-succinyllysine.
Modified residue: 270 270 N6-acetyllysine.
Modified residue: 335 335 N6-acetyllysine.

Protein Length

424 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005743; C:mitochondrial inner membrane; IDA:MGI
GO:0005759; C:mitochondrial matrix; IEA:Ensembl
GO:0005739; C:mitochondrion; IDA:MGI
GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IDA:MGI
GO:0050662; F:coenzyme binding; IEA:Ensembl
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0060612; P:adipose tissue development; IEA:Ensembl
GO:0007420; P:brain development; IEA:Ensembl
GO:0001889; P:liver development; IEA:Ensembl
GO:0072229; P:metanephric proximal convoluted tubule development; IEA:Ensembl
GO:0051260; P:protein homooligomerization; IEA:Ensembl
GO:0009725; P:response to hormone; IEA:Ensembl
GO:0014070; P:response to organic cyclic compound; IEA:Ensembl
GO:0042594; P:response to starvation; IEA:Ensembl

Interpro

InterPro; IPR002155; Thiolase
InterPro; IPR016039; Thiolase-like
InterPro; IPR016038; Thiolase-like_subgr
InterPro; IPR020615; Thiolase_acyl_enz_int_AS
InterPro; IPR020610; Thiolase_AS
InterPro; IPR020617; Thiolase_C
InterPro; IPR020613; Thiolase_CS
InterPro; IPR020616; Thiolase_N

Pfam

Pfam; PF02803; Thiolase_C;
Pfam; PF00108; Thiolase_N;

SMART

PROSITE

PROSITE; PS00098; THIOLASE_1;
PROSITE; PS00737; THIOLASE_2;
PROSITE; PS00099; THIOLASE_3;

PRINTS