Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00299
Entry Name
UniProt Accession
Theoretical PI
5.27
Molecular Weight
38522.81
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Nuclear distribution protein nudE homolog 1
Protein Synonyms/Alias
NudE; mNudE;
Gene Name
Nde1
Gene Synonyms/Alias
Nude;
Created Date
13-JUN-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
274
Canonical
LESKLASCRNFMYDQ
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S, FukataY, Orr I, Fukata M, Reiner O. Ndel1 palmitoylation: a new mean to regulatecytoplasmic dynein activity. EMBO J. 2010 Jan 6;29(1):107-19. doi:10.1038/emboj.2009.325. Epub 2009 Nov 19.[PMID:19927128]
Functional Description
Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a post- mitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex.
Sequence Annotation
Region: 1 93 Self-association.
Region: 88 156 Interaction with PAFAH1B1.
Region: 167 290 Interaction with CENPF.
Modified residue: 211 211 Phosphoserine.
Modified residue: 215 215 Phosphothreonine.
Modified residue: 228 228 Phosphothreonine.
Modified residue: 239 239 Phosphoserine.
Modified residue: 243 243 Phosphothreonine.
Modified residue: 246 246 Phosphothreonine.
Modified residue: 282 282 Phosphoserine.
Protein Length
344 AA.
Protein Sequence
(Canonical)
MEDSGKTFES EEEETNYWRD LAMTYKQRAE NTQEELREFQ EGSREYEAEL EAQLQQIETR  60
NRDLLSENNR LRMELESVKE KFEMQHSEGY RQISALEDDL AQTKAIKDQL QKYIRELEQA  120
NDDLERAKRA TIMSLEDFEQ RLNQAIERNA FLESELDEKE NLLESVQRLK DEARDLRQEL  180
AVQQKQDKPR TPMPGSGQAK RTDMAVQATG SVPSTPVAHR GPSSGLNTPG MFRRGLDSST  240
SGTPLTPAAR ISALNIVGDL LRKVGALESK LASCRNFMYD QSPSRTSGPA SGRGTKNRDG  300
VDRRPGSTSV GDKGSGKRLE FGKPASEPAS PALPSAQGVV KLLL                   344
FASTA
(Canonical)
>LipidDB-10090-00299|Q9CZA6
MEDSGKTFESEEEETNYWRDLAMTYKQRAENTQEELREFQEGSREYEAELEAQLQQIETR
NRDLLSENNRLRMELESVKEKFEMQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQA
NDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQEL
AVQQKQDKPRTPMPGSGQAKRTDMAVQATGSVPSTPVAHRGPSSGLNTPGMFRRGLDSST
SGTPLTPAARISALNIVGDLLRKVGALESKLASCRNFMYDQSPSRTSGPASGRGTKNRDG
VDRRPGSTSVGDKGSGKRLEFGKPASEPASPALPSAQGVVKLLL
Gene Ontology
GO:0005813; C:centrosome; IDA:MGI
GO:0005737; C:cytoplasm; IEA:UniProtKB-KW
GO:0000776; C:kinetochore; IEA:UniProtKB-KW
GO:0005874; C:microtubule; IEA:UniProtKB-KW
GO:0005815; C:microtubule organizing center; IDA:UniProtKB
GO:0005819; C:spindle; IDA:MGI
GO:0031616; C:spindle pole centrosome; IDA:UniProtKB
GO:0042802; F:identical protein binding; IPI:MGI
GO:0008017; F:microtubule binding; IMP:UniProtKB
GO:0051298; P:centrosome duplication; IMP:UniProtKB
GO:0021987; P:cerebral cortex development; IGI:MGI
GO:0051303; P:establishment of chromosome localization; IEA:Ensembl
GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl
GO:0030900; P:forebrain development; IMP:MGI
GO:0007020; P:microtubule nucleation; IDA:MGI
GO:0031023; P:microtubule organizing center organization; IMP:UniProtKB
GO:0007067; P:mitotic nuclear division; IEA:UniProtKB-KW
GO:0007405; P:neuroblast proliferation; IMP:MGI
GO:0001764; P:neuron migration; IMP:UniProtKB
GO:0047496; P:vesicle transport along microtubule; IGI:MGI
Interpro
InterPro; IPR006964; NUDE_C
Pfam
Pfam; PF04880; NUDE_C;
SMART
PROSITE
PRINTS