LipidDB ID

LipidDB-10090-00295

Entry Name

UniProt Accession

P70452; Q3TSL5; Q3UKQ8; Q80WT8;

Theoretical PI

5.84

Molecular Weight

34164.99

Genbank Protein ID

AAB18991.1; BAE26743.1; BAE36660.1; AAH05791.1; AAH11491.1; AAH52023.1;

Genbank Nucleotide ID

U76832; AK145909; AK161971; BC005791; BC011491; BC052023;

Protein Name

Syntaxin-4

Protein Synonyms/Alias

Gene Name

Stx4

Gene Synonyms/Alias

Stx4a;

Created Date

01-NOV-1997

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.

Sequence Annotation

Topological domain: 1 274 Cytoplasmic.
Transmembrane: 275 295 Helical; Anchor for type IV membraneprotein.
Topological domain: 296 298 Extracellular.
Domain: 200 262 t-SNARE coiled-coil homology.
Region: 154 298 Interaction with CENPF.
Modified residue: 15 15 Phosphoserine.
Modified residue: 29 29 Phosphoserine.
Modified residue: 117 117 Phosphoserine.
Modified residue: 248 248 Phosphoserine.

Protein Length

298 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0016323; C:basolateral plasma membrane; IDA:MGI
GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0005737; C:cytoplasm; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0043219; C:lateral loop; IDA:BHF-UCL
GO:0035749; C:myelin sheath adaxonal region; IDA:BHF-UCL
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB
GO:0005886; C:plasma membrane; IDA:MGI
GO:0031201; C:SNARE complex; ISS:UniProtKB
GO:0042581; C:specific granule; IEA:Ensembl
GO:0005802; C:trans-Golgi network; IDA:UniProtKB
GO:0000149; F:SNARE binding; IPI:UniProtKB
GO:0006886; P:intracellular protein transport; IEA:InterPro
GO:0035493; P:SNARE complex assembly; IDA:BHF-UCL
GO:0016079; P:synaptic vesicle exocytosis; TAS:MGI

Interpro

InterPro; IPR006012; Syntaxin/epimorphin_CS
InterPro; IPR006011; Syntaxin_N
InterPro; IPR010989; t-SNARE
InterPro; IPR000727; T_SNARE_dom

Pfam

Pfam; PF05739; SNARE;
Pfam; PF00804; Syntaxin;

SMART

SMART; SM00503; SynN;
SMART; SM00397; t_SNARE;

PROSITE

PROSITE; PS00914; SYNTAXIN;
PROSITE; PS50192; T_SNARE;

PRINTS