LipidDB-10090-00268

Lipid Modification Database

Tag

Content

LipidDB ID

LipidDB-10090-00268

Entry Name

MSRA_MOUSE

UniProt Accession

Q9D6Y7; Q5EBQ7; Q91WK9; Q9DCY2;

Theoretical PI

8.6

Molecular Weight

25988.37

Genbank Protein ID

BAB22035.1; BAB26522.1; BAC33889.1; EDL36048.1; AAH14738.1; AAH89311.1;

Genbank Nucleotide ID

AK002356; AK009822; AK049714; AK018338; CH466535; BC014738; BC089311;

Protein Name

Mitochondrial peptide methionine sulfoxide reductase

Protein Synonyms/Alias

1.8.4.11; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Protein-methionine-S-oxide reductase; PMSR;

Gene Name

Msra

Gene Synonyms/Alias

Created Date

15-MAR-2004

Lipid Modification Sites
Position	Sequence Form	Peptide	References	Modification Type
2	Isoform 2	******MGDSASKVI	[1][2]	N-Myristoylation

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Zhao H, Sun J, Deschamps AM, Kim G, Liu C, Murphy E, Levine RL. Myristoylated methionine sulfoxide reductase A protects the heart from ischemia-reperfusioninjury. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1513-8. doi:10.1152/ajpheart.00441.2011. Epub 2011 Aug 12.[PMID:21841012]
[2] Kim G, Cole NB, Lim JC, Zhao H, Levine RL. Dual sites of protein initiationcontrol the localization and myristoylation of methionine sulfoxide reductase A. J Biol Chem. 2010 Jun 4;285(23):18085-94. doi: 10.1074/jbc.M110.119701. Epub 2010Apr 5.[PMID:20368336]

Functional Description

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).

Sequence Annotation

Modified residue: 104 104 N6-acetyllysine; alternate.
Modified residue: 104 104 N6-succinyllysine; alternate.
Modified residue: 183 183 N6-acetyllysine; alternate.
Modified residue: 183 183 N6-succinyllysine; alternate.

Protein Length

233 AA.

Protein Sequence
(Isoform 2)

MGDSASKVIS AEEALPGRTE PIPVTAKHHV SGNRTVEPFP EGTQMAVFGM GCFWGAERKF  60
WVLKGVYSTQ VGFAGGHTRN PTYKEVCSEK TGHAEVVRVV YRPEHISFEE LLKVFWENHD  120
PTQGMRQGND FGTQYRSAVY PTSAVQMEAA LRSKEEYQKV LSKHNFGPIT TDIREGQVFY  180
YAEDYHQQYL SKNPDGYCGL GGTGVSCPMA IKK                               213

FASTA
(Isoform 2)

>LipidDB-10090-00268|Q9D6Y7-2
MGDSASKVISAEEALPGRTEPIPVTAKHHVSGNRTVEPFPEGTQMAVFGMGCFWGAERKF
WVLKGVYSTQVGFAGGHTRNPTYKEVCSEKTGHAEVVRVVYRPEHISFEELLKVFWENHD
PTQGMRQGNDFGTQYRSAVYPTSAVQMEAALRSKEEYQKVLSKHNFGPITTDIREGQVFY
YAEDYHQQYLSKNPDGYCGLGGTGVSCPMAIKK

Gene Ontology

GO:0005737; C:cytoplasm; IDA:MGI
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0016020; C:membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IDA:MGI
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IMP:MGI
GO:0030091; P:protein repair; IEA:InterPro
GO:0006979; P:response to oxidative stress; IEA:InterPro

Interpro

InterPro; IPR028427; Met_Sox_Rdtase
InterPro; IPR002569; Met_Sox_Rdtase_MsrA

Pfam

Pfam; PF01625; PMSR;

SMART

PROSITE

PRINTS