| Tag |
Content |
LipidDB ID |
LipidDB-10090-00254 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
6.81 |
Molecular Weight |
15743.14 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Interferon-induced transmembrane protein 2 |
Protein Synonyms/Alias |
Dispanin subfamily A member 2c; DSPA2c; Fragilis protein 3; |
Gene Name |
Ifitm2 |
Gene Synonyms/Alias |
|
Created Date |
05-OCT-2010 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
70 | Canonical | NTLFFNACCLGFVAY | [1] | S-Palmitoylation | 71 | Canonical | TLFFNACCLGFVAYA | [1] | S-Palmitoylation | 104 | Canonical | AYASTAKCLNISSLI | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53- independent manner. |
Sequence Annotation |
Topological domain: 1 56 Cytoplasmic.
Topological domain: 78 110 Cytoplasmic.
Transmembrane: 111 131 Helical.
Topological domain: 132 144 Extracellular.
Modified residue: 1 1 N-acetylmethionine.
|
Protein Length |
144 AA. |
Protein Sequence
(Canonical) |
MSHNSQAFLS TNAGLPPSYE TIKEEYGVTE LGEPSNSAVV RTTVINMPRE VSVPDHVVWS 60
LFNTLFFNAC CLGFVAYAYS VKSRDRKMVG DVVGAQAYAS TAKCLNISSL IFSILMVIIC 120
IIIFSTTSVV VFQSFAQRTP HSGF 144
|
FASTA
(Canonical) |
>LipidDB-10090-00254|Q99J93
MSHNSQAFLSTNAGLPPSYETIKEEYGVTELGEPSNSAVVRTTVINMPREVSVPDHVVWS
LFNTLFFNACCLGFVAYAYSVKSRDRKMVGDVVGAQAYASTAKCLNISSLIFSILMVIIC
IIIFSTTSVVVFQSFAQRTPHSGF
|
Gene Ontology |
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0005886; C:plasma membrane; IEA:UniProtKB-KW GO:0051607; P:defense response to virus; IDA:MGI GO:0045087; P:innate immune response; IEA:UniProtKB-KW GO:0046597; P:negative regulation of viral entry into host cell; IDA:UniProtKB GO:0009615; P:response to virus; IDA:UniProtKB |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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