Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00252
Entry Name
UniProt Accession
Theoretical PI
8.37
Molecular Weight
73244.39
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
ATP-binding cassette sub-family G member 5
Protein Synonyms/Alias
Sterolin-1;
Gene Name
Abcg5
Gene Synonyms/Alias
Created Date
05-DEC-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
61
Canonical
PWWNIKSCQQKWDRQ
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Wang J, Zhang DW, Lei Y, Xu F, Cohen JC, Hobbs HH, Xie XS. Purification andreconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry. 2008 May 6;47(18):5194-204. doi: 10.1021/bi800292v. Epub 2008 Apr 11. PubMedPMID: 18402465; PubMed Central PMCID: PMC2707165.[PMID:18402465]
Functional Description
Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Sequence Annotation
Topological domain: 1 385 Cytoplasmic.
Transmembrane: 386 406 Helical; Name=1.
Topological domain: 407 422 Extracellular.
Transmembrane: 423 443 Helical; Name=2.
Topological domain: 444 463 Cytoplasmic.
Transmembrane: 464 484 Helical; Name=3.
Topological domain: 485 504 Extracellular.
Transmembrane: 505 525 Helical; Name=4.
Topological domain: 526 529 Cytoplasmic.
Transmembrane: 530 550 Helical; Name=5.
Topological domain: 551 622 Extracellular.
Transmembrane: 623 643 Helical; Name=6.
Topological domain: 644 652 Cytoplasmic.
Domain: 39 294 ABC transporter.
Domain: 389 646 ABC transmembrane type-2.
Nucleotide-binding: 87 94 ATP.
Protein Length
652 AA.
Protein Sequence
(Canonical)
MGELPFLSPE GARGPHINRG SLSSLEQGSV TGTEARHSLG VLHVSYSVSN RVGPWWNIKS  60
CQQKWDRQIL KDVSLYIESG QIMCILGSSG SGKTTLLDAI SGRLRRTGTL EGEVFVNGCE  120
LRRDQFQDCF SYVLQSDVFL SSLTVRETLR YTAMLALCRS SADFYNKKVE AVMTELSLSH  180
VADQMIGSYN FGGISSGERR RVSIAAQLLQ DPKVMMLDEP TTGLDCMTAN QIVLLLAELA  240
RRDRIVIVTI HQPRSELFQH FDKIAILTYG ELVFCGTPEE MLGFFNNCGY PCPEHSNPFD  300
FYMDLTSVDT QSREREIETY KRVQMLECAF KESDIYHKIL ENIERARYLK TLPTVPFKTK  360
DPPGMFGKLG VLLRRVTRNL MRNKQAVIMR LVQNLIMGLF LIFYLLRVQN NTLKGAVQDR  420
VGLLYQLVGA TPYTGMLNAV NLFPMLRAVS DQESQDGLYH KWQMLLAYVL HVLPFSVIAT  480
VIFSSVCYWT LGLYPEVARF GYFSAALLAP HLIGEFLTLV LLGIVQNPNI VNSIVALLSI  540
SGLLIGSGFI RNIQEMPIPL KILGYFTFQK YCCEILVVNE FYGLNFTCGG SNTSMLNHPM  600
CAITQGVQFI EKTCPGATSR FTANFLILYG FIPALVILGI VIFKVRDYLI SR          652
FASTA
(Canonical)
>LipidDB-10090-00252|Q99PE8
MGELPFLSPEGARGPHINRGSLSSLEQGSVTGTEARHSLGVLHVSYSVSNRVGPWWNIKS
CQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCE
LRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRSSADFYNKKVEAVMTELSLSH
VADQMIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELA
RRDRIVIVTIHQPRSELFQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFD
FYMDLTSVDTQSREREIETYKRVQMLECAFKESDIYHKILENIERARYLKTLPTVPFKTK
DPPGMFGKLGVLLRRVTRNLMRNKQAVIMRLVQNLIMGLFLIFYLLRVQNNTLKGAVQDR
VGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYHKWQMLLAYVLHVLPFSVIAT
VIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSIVALLSI
SGLLIGSGFIRNIQEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSMLNHPM
CAITQGVQFIEKTCPGATSRFTANFLILYGFIPALVILGIVIFKVRDYLISR
Gene Ontology
GO:0045177; C:apical part of cell; IDA:MGI
GO:0016324; C:apical plasma membrane; IMP:BHF-UCL
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0016020; C:membrane; IDA:MGI
GO:0005524; F:ATP binding; IEA:UniProtKB-KW
GO:0016887; F:ATPase activity; IEA:Ensembl
GO:0033344; P:cholesterol efflux; IMP:BHF-UCL
GO:0042632; P:cholesterol homeostasis; IEA:Ensembl
GO:0007588; P:excretion; IMP:BHF-UCL
GO:0030299; P:intestinal cholesterol absorption; IC:BHF-UCL
GO:0045796; P:negative regulation of intestinal cholesterol absorption; IEA:Ensembl
GO:0010949; P:negative regulation of intestinal phytosterol absorption; IEA:Ensembl
GO:0042493; P:response to drug; IEA:Ensembl
GO:0010212; P:response to ionizing radiation; IEA:Ensembl
GO:0007584; P:response to nutrient; IEA:Ensembl
Interpro
InterPro; IPR003593; AAA+_ATPase
InterPro; IPR013525; ABC_2_trans
InterPro; IPR003439; ABC_transporter-like
InterPro; IPR017871; ABC_transporter_CS
InterPro; IPR027417; P-loop_NTPase
Pfam
Pfam; PF01061; ABC2_membrane;
Pfam; PF00005; ABC_tran;
SMART
SMART; SM00382; AAA;
PROSITE
PROSITE; PS00211; ABC_TRANSPORTER_1;
PROSITE; PS50893; ABC_TRANSPORTER_2;
PRINTS