| Tag |
Content |
LipidDB ID |
LipidDB-10090-00232 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.8 |
Molecular Weight |
64514.5 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Polypeptide N-acetylgalactosaminyltransferase 2 soluble form |
Protein Synonyms/Alias |
2.4.1.41; Polypeptide GalNAc transferase 2; GalNAc-T2; pp-GaNTase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; |
Gene Name |
Galnt2 |
Gene Synonyms/Alias |
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Created Date |
16-AUG-2004 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
10 | Canonical | RRSRMLLCFALLWVL | [1] | S-Palmitoylation | 226 | Canonical | LTFLDSHCECNERWL | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Predicted from GPS-Lipid
|
Functional Description |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity). |
Sequence Annotation |
Topological domain: 1 6 Cytoplasmic.
Transmembrane: 7 24 Helical; Signal-anchor for type IImembrane protein.
Topological domain: 25 570 Lumenal.
Domain: 442 565 Ricin B-type lectin.
Region: 134 239 Catalytic subdomain A.
Region: 299 361 Catalytic subdomain B.
Metal binding site: 223 223 Manganese.
Metal binding site: 225 225 Manganese.
Metal binding site: 358 358 Manganese.
Binding site: 142 142 Substrate.
Binding site: 175 175 Substrate.
Binding site: 200 200 Substrate.
Binding site: 224 224 Substrate.
Binding site: 330 330 Substrate.
Binding site: 361 361 Substrate.
Binding site: 364 364 Substrate.
Binding site: 366 366 Substrate.
|
Protein Length |
570 AA. |
Protein Sequence
(Canonical) |
MRRRSRMLLC FALLWVLGIA YYMYSGGGSA LAAGGGGAGR KGDWNDIDSI KKKDLHHSRG 60
DEKAQGVETL PPGKVRWPDF NQEAYVGGTM VRSGQDPYAR NKFNQVESDK LHMDRGIPDT 120
RHDQCQRKQW RVDLPATSVV ITFHNEARSA LLRTVVSVLK RSPPHLIKEI ILVDDYSNDP 180
EDGALLGKIE KVRVLRNDRR EGLMRSRVRG ADAAQAKVLT FLDSHCECNE RWLEPLLERV 240
AEDRTRVVSP IIDVINMDNF QYVGASADLK GGFDWNLVFK WDYMTPEQRR SRQGNPVAPI 300
KTPMIAGGLF VMDKLYFEEL GKYDMMMDVW GGENLEISFR VWQCGGSLEI IPCSRVGHVF 360
RKQHPYTFPG GSGTVFARNT RRAAEVWMDE YKHFYYAAVP SARNVPYGNI QSRLELRKKL 420
GCKPFKWYLD NVYPELRVPD HQDIAFGALQ QGTNCLDTLG HFADGVVGIY ECHNAGGNQE 480
WALTKEKSVK HMDLCLTVVD RSPGSLIRLQ GCRENDSRQK WEQIEGNSKL RHVGSNLCLD 540
SRTAKSGGLS VEVCGPALSQ QWKFSLNLQQ 570
|
FASTA
(Canonical) |
>LipidDB-10090-00232|Q6PB93
MRRRSRMLLCFALLWVLGIAYYMYSGGGSALAAGGGGAGRKGDWNDIDSIKKKDLHHSRG
DEKAQGVETLPPGKVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLHMDRGIPDT
RHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKRSPPHLIKEIILVDDYSNDP
EDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNERWLEPLLERV
AEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPI
KTPMIAGGLFVMDKLYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVF
RKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKHFYYAAVPSARNVPYGNIQSRLELRKKL
GCKPFKWYLDNVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGIYECHNAGGNQE
WALTKEKSVKHMDLCLTVVDRSPGSLIRLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLD
SRTAKSGGLSVEVCGPALSQQWKFSLNLQQ
|
Gene Ontology |
GO:0005576; C:extracellular region; IEA:UniProtKB-KW GO:0005796; C:Golgi lumen; TAS:MGI GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW GO:0030145; F:manganese ion binding; ISS:UniProtKB GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; ISS:UniProtKB GO:0006493; P:protein O-linked glycosylation; ISS:UniProtKB |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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