Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00226
Entry Name
UniProt Accession
Theoretical PI
5.67
Molecular Weight
24677.73
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Regulator of G-protein signaling 19
Protein Synonyms/Alias
RGS19;
Gene Name
Rgs19
Gene Synonyms/Alias
Created Date
14-AUG-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
39
Canonical
GPPSRNPCCLCWCCC
[1]
S-Palmitoylation
40
Canonical
PPSRNPCCLCWCCCC
[1]
S-Palmitoylation
42
Canonical
SRNPCCLCWCCCCSC
[1]
S-Palmitoylation
44
Canonical
NPCCLCWCCCCSCSW
[1]
S-Palmitoylation
45
Canonical
PCCLCWCCCCSCSWN
[1]
S-Palmitoylation
46
Canonical
CCLCWCCCCSCSWNQ
[1]
S-Palmitoylation
47
Canonical
CLCWCCCCSCSWNQE
[1]
S-Palmitoylation
49
Canonical
CWCCCCSCSWNQERQ
[1]
S-Palmitoylation
123
Canonical
NMLFWLACEELKAEA
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity).
Sequence Annotation
Domain: 90 206 RGS.
Region: 207 216 Interaction with GIPC.
Modified residue: 24 24 Phosphoserine.
Modified residue: 97 97 Phosphoserine.
Modified residue: 151 151 Phosphoserine; by MAPK1 and MAPK3.
Protein Length
216 AA.
Protein Sequence
(Canonical)
MPTPHEAEKQ HTGPEEADRP PSMSSHDAAP SGPPSRNPCC LCWCCCCSCS WNQERQRAWQ  60
VSRESKLQPL PSCEVCTPPS PKEVQSWAQS FDKLMHSPTG RSVFRAFLRT EYSEENMLFW  120
LACEELKAEA NQHVVDEKAR LIYEDYVSIL SPKEVSLDSR VREGINRKMQ EPSPHTFDDA  180
QLQIYTLMHR DSYPRFLTSP TYRSLLLQGA PQSSEA                            216
FASTA
(Canonical)
>LipidDB-10090-00226|Q9CX84
MPTPHEAEKQHTGPEEADRPPSMSSHDAAPSGPPSRNPCCLCWCCCCSCSWNQERQRAWQ
VSRESKLQPLPSCEVCTPPSPKEVQSWAQSFDKLMHSPTGRSVFRAFLRTEYSEENMLFW
LACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINRKMQEPSPHTFDDA
QLQIYTLMHRDSYPRFLTSPTYRSLLLQGAPQSSEA
Gene Ontology
GO:0005903; C:brush border; IEA:Ensembl
GO:0030136; C:clathrin-coated vesicle; IEA:Ensembl
GO:0005737; C:cytoplasm; IBA:RefGenome
GO:0005886; C:plasma membrane; IBA:RefGenome
GO:0005096; F:GTPase activator activity; IBA:RefGenome
GO:0043547; P:positive regulation of GTPase activity; IBA:GOC
GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro
Interpro
InterPro; IPR024066; Regulat_G_prot_signal_dom1
InterPro; IPR016137; Regulat_G_prot_signal_superfam
InterPro; IPR000342; RGS_dom
Pfam
Pfam; PF00615; RGS;
SMART
SMART; SM00315; RGS;
PROSITE
PROSITE; PS50132; RGS;
PRINTS
PRINTS; PR01301; RGSPROTEIN;