LipidDB ID

LipidDB-10090-00186

Entry Name

UniProt Accession

O09126; Q6GTM9;

Theoretical PI

8.04

Molecular Weight

95640.18

Genbank Protein ID

AAC52964.1; EDL41105.1; EDL41106.1; EDL41107.1; AAH49780.2;

Genbank Nucleotide ID

U69535; CH466546; CH466546; CH466546; BC049780;

Protein Name

Semaphorin-4D

Protein Synonyms/Alias

M-Sema G; Semaphorin-C-like 2; Semaphorin-J; Sema J; CD100;

Gene Name

Sema4d

Gene Synonyms/Alias

Semacl2; Semaj;

Created Date

30-MAY-2000

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).

Sequence Annotation

Topological domain: 24 733 Extracellular.
Transmembrane: 734 754 Helical.
Topological domain: 755 861 Cytoplasmic.
Domain: 24 500 Sema.
Domain: 502 551 PSI.
Domain: 555 636 Ig-like C2-type.

Protein Length

861 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005615; C:extracellular space; IDA:BHF-UCL
GO:0005887; C:integral component of plasma membrane; IEA:Ensembl
GO:0016020; C:membrane; TAS:BHF-UCL
GO:0005102; F:receptor binding; IPI:MGI
GO:0030215; F:semaphorin receptor binding; IPI:BHF-UCL
GO:0004888; F:transmembrane signaling receptor activity; ISS:UniProtKB
GO:0070486; P:leukocyte aggregation; ISS:UniProtKB
GO:0010693; P:negative regulation of alkaline phosphatase activity; IDA:BHF-UCL
GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB
GO:0045668; P:negative regulation of osteoblast differentiation; IMP:BHF-UCL
GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL
GO:0043931; P:ossification involved in bone maturation; IMP:BHF-UCL
GO:0050772; P:positive regulation of axonogenesis; IDA:MGI
GO:0030335; P:positive regulation of cell migration; IDA:BHF-UCL
GO:0048672; P:positive regulation of collateral sprouting; ISS:UniProtKB
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:BHF-UCL
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB
GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB
GO:0032321; P:positive regulation of Rho GTPase activity; IMP:BHF-UCL
GO:0031344; P:regulation of cell projection organization; ISS:UniProtKB
GO:0008360; P:regulation of cell shape; ISS:UniProtKB
GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB
GO:0071526; P:semaphorin-plexin signaling pathway; ISS:UniProtKB
GO:1900220; P:semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis; IMP:BHF-UCL

Interpro

InterPro; IPR007110; Ig-like_dom
InterPro; IPR013783; Ig-like_fold
InterPro; IPR003599; Ig_sub
InterPro; IPR016201; Plexin-like_fold
InterPro; IPR002165; Plexin_repeat
InterPro; IPR001627; Semap_dom
InterPro; IPR027231; Semaphorin
InterPro; IPR015943; WD40/YVTN_repeat-like_dom

Pfam

Pfam; PF01437; PSI;
Pfam; PF01403; Sema;

SMART

SMART; SM00409; IG;
SMART; SM00423; PSI;
SMART; SM00630; Sema;

PROSITE

PROSITE; PS50835; IG_LIKE;
PROSITE; PS51004; SEMA;

PRINTS