LipidDB ID

LipidDB-10090-00183

Entry Name

UniProt Accession

P68181; P05206; Q3TQH5; Q3UDD0; Q3UTH5;

Theoretical PI

8.65

Molecular Weight

40707.86

Genbank Protein ID

AAA39941.1; BAC33301.1; BAE24005.1; BAE28648.1; BAE29323.1; BAE29331.1; BAE37407.1; AAH54533.1; AAA39938.1; CAA43676.1;

Genbank Nucleotide ID

J02626; AK048319; AK139419; AK148728; AK150122; AK150134; AK163585; BC054533; M21096; AF022239; X61434;

Protein Name

cAMP-dependent protein kinase catalytic subunit beta

Protein Synonyms/Alias

PKA C-beta; 2.7.11.11;

Gene Name

Prkacb

Gene Synonyms/Alias

Pkacb;

Created Date

13-AUG-1987

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Guthrie CR, Skâlhegg BS, McKnight GS. Two novel brain-specific splice variantsof the murine Cbeta gene of cAMP-dependent protein kinase. J Biol Chem. 1997 Nov 21;272(47):29560-5.[PMID:9368018]

Functional Description

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity).

Sequence Annotation

Domain: 44 298 Protein kinase.
Domain: 299 351 AGC-kinase C-terminal.
Nucleotide-binding: 50 58 ATP.
Active site: 167 167 Proton acceptor.
Binding site: 73 73 ATP.
Modified residue: 3 3 Deamidated asparagine.
Modified residue: 11 11 Phosphoserine.
Modified residue: 49 49 Phosphothreonine.
Modified residue: 69 69 Phosphotyrosine.
Modified residue: 140 140 Phosphoserine.
Modified residue: 196 196 Phosphothreonine.
Modified residue: 198 198 Phosphothreonine.
Modified residue: 202 202 Phosphothreonine.
Modified residue: 331 331 Phosphotyrosine.
Modified residue: 339 339 Phosphoserine.

Protein Length

351 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005952; C:cAMP-dependent protein kinase complex; TAS:UniProtKB
GO:0005813; C:centrosome; IEA:Ensembl
GO:0097546; C:ciliary base; IDA:MGI
GO:0005829; C:cytosol; TAS:Reactome
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005634; C:nucleus; IEA:UniProtKB-KW
GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0005524; F:ATP binding; IDA:UniProtKB
GO:0004691; F:cAMP-dependent protein kinase activity; IDA:UniProtKB
GO:0000287; F:magnesium ion binding; IDA:UniProtKB
GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:UniProtKB
GO:0051447; P:negative regulation of meiotic cell cycle; IEA:Ensembl
GO:1901621; P:negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IGI:MGI
GO:0001843; P:neural tube closure; IGI:MGI
GO:0006468; P:protein phosphorylation; IDA:UniProtKB
GO:0070613; P:regulation of protein processing; IGI:MGI
GO:0097338; P:response to clozapine; IEA:Ensembl

Interpro

InterPro; IPR000961; AGC-kinase_C
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR002290; Ser/Thr_dual-sp_kinase
InterPro; IPR008271; Ser/Thr_kinase_AS

Pfam

Pfam; PF00069; Pkinase;

SMART

SMART; SM00133; S_TK_X;
SMART; SM00220; S_TKc;

PROSITE

PROSITE; PS51285; AGC_KINASE_CTER;
PROSITE; PS00107; PROTEIN_KINASE_ATP;
PROSITE; PS50011; PROTEIN_KINASE_DOM;
PROSITE; PS00108; PROTEIN_KINASE_ST;

PRINTS