LipidDB ID

LipidDB-10090-00175

Entry Name

UniProt Accession

P08752; Q3TXK7; Q6P1C0;

Theoretical PI

5.28

Molecular Weight

40488.97

Genbank Protein ID

AAA37692.1; BAE34308.1; BAE34909.1; BAE39478.1; AAH65159.1; AAB30632.2;

Genbank Nucleotide ID

M13963; AK157998; AK159222; AK167388; BC065159; S71213;

Protein Name

Guanine nucleotide-binding protein G(i) subunit alpha-2

Protein Synonyms/Alias

Adenylate cyclase-inhibiting G alpha protein;

Gene Name

Gnai2

Gene Synonyms/Alias

Gnai-2;

Created Date

01-NOV-1988

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid
[2] Gallego C, Gupta SK, Winitz S, Eisfelder BJ, Johnson GL. Myristoylation of theG alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions. Proc Natl Acad Sci U S A. 1992 Oct15;89(20):9695-9.[PMID:1409685]

Functional Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.

Sequence Annotation

Nucleotide-binding: 40 47 GTP.
Nucleotide-binding: 176 182 GTP.
Nucleotide-binding: 201 205 GTP.
Nucleotide-binding: 270 273 GTP.
Metal binding site: 47 47 Magnesium.
Metal binding site: 182 182 Magnesium.
Binding site: 327 327 GTP; via amide nitrogen.

Protein Length

355 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005813; C:centrosome; ISS:UniProtKB
GO:0005737; C:cytoplasm; ISS:UniProtKB
GO:0005829; C:cytosol; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome
GO:0045121; C:membrane raft; IEA:Ensembl
GO:0030496; C:midbody; ISS:UniProtKB
GO:0005634; C:nucleus; IEA:Ensembl
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome
GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome
GO:0005525; F:GTP binding; ISA:MGI
GO:0003924; F:GTPase activity; IBA:RefGenome
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0004871; F:signal transducer activity; IBA:RefGenome
GO:0000186; P:activation of MAPKK activity; IEA:Ensembl
GO:0001973; P:adenosine receptor signaling pathway; IBA:RefGenome
GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IMP:MGI
GO:0007049; P:cell cycle; IEA:UniProtKB-KW
GO:0051301; P:cell division; ISS:UniProtKB
GO:0008283; P:cell proliferation; IPI:MGI
GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IMP:MGI
GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:RefGenome
GO:0050805; P:negative regulation of synaptic transmission; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl
GO:0051924; P:regulation of calcium ion transport; IEA:Ensembl

Interpro

InterPro; IPR001408; Gprotein_alpha_I
InterPro; IPR001019; Gprotein_alpha_su
InterPro; IPR011025; GproteinA_insert
InterPro; IPR027417; P-loop_NTPase

Pfam

Pfam; PF00503; G-alpha;

SMART

SMART; SM00275; G_alpha;

PROSITE

PRINTS

PRINTS; PR00318; GPROTEINA;
PRINTS; PR00441; GPROTEINAI;