Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00161
Entry Name
UniProt Accession
Theoretical PI
7.44
Molecular Weight
31732.84
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Voltage-dependent anion-selective channel protein 2
Protein Synonyms/Alias
VDAC-2; mVDAC2; Outer mitochondrial membrane protein porin 2; Voltage-dependent anion-selective channel protein 6; VDAC-6; mVDAC6;
Gene Name
Vdac2
Gene Synonyms/Alias
Vdac6;
Created Date
15-JUL-1999
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
4
Canonical
****MAECCVPVCPR
[1]
S-Palmitoylation
5
Canonical
***MAECCVPVCPRP
[1]
S-Palmitoylation
9
Canonical
AECCVPVCPRPMCIP
[1]
S-Palmitoylation
14
Canonical
PVCPRPMCIPPPYAD
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective (By similarity).
Sequence Annotation
Transmembrane: 38 47 Beta stranded.
Transmembrane: 51 59 Beta stranded.
Transmembrane: 66 76 Beta stranded.
Transmembrane: 81 88 Beta stranded.
Transmembrane: 92 101 Beta stranded.
Transmembrane: 107 116 Beta stranded.
Transmembrane: 123 132 Beta stranded.
Transmembrane: 135 142 Beta stranded.
Transmembrane: 149 157 Beta stranded.
Transmembrane: 162 170 Beta stranded.
Transmembrane: 175 187 Beta stranded.
Transmembrane: 190 197 Beta stranded.
Transmembrane: 201 210 Beta stranded.
Transmembrane: 214 223 Beta stranded.
Transmembrane: 230 239 Beta stranded.
Transmembrane: 243 250 Beta stranded.
Transmembrane: 254 263 Beta stranded.
Transmembrane: 266 275 Beta stranded.
Transmembrane: 285 294 Beta stranded.
Nucleotide-binding: 254 256 NAD.
Nucleotide-binding: 272 276 NAD.
Functional site: 85 85 Involved in hexokinase binding.
Modified residue: 32 32 N6-acetyllysine; alternate.
Modified residue: 32 32 N6-succinyllysine; alternate.
Modified residue: 121 121 N6-acetyllysine.
Protein Length
295 AA.
Protein Sequence
(Canonical)
MAECCVPVCP RPMCIPPPYA DLGKAARDIF NKGFGFGLVK LDVKTKSCSG VEFSTSGSSN  60
TDTGKVSGTL ETKYKWCEYG LTFTEKWNTD NTLGTEIAIE DQICQGLKLT FDTTFSPNTG  120
KKSGKIKSAY KRECINLGCD VDFDFAGPAI HGSAVFGYEG WLAGYQMTFD SAKSKLTRSN  180
FAVGYRTGDF QLHTNVNNGT EFGGSIYQKV CEDFDTSVNL AWTSGTNCTR FGIAAKYQLD  240
PTASISAKVN NSSLIGVGYT QTLRPGVKLT LSALVDGKSF NAGGHKLGLA LELEA       295
FASTA
(Canonical)
>LipidDB-10090-00161|Q60930
MAECCVPVCPRPMCIPPPYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSN
TDTGKVSGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTG
KKSGKIKSAYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRSN
FAVGYRTGDFQLHTNVNNGTEFGGSIYQKVCEDFDTSVNLAWTSGTNCTRFGIAAKYQLD
PTASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSFNAGGHKLGLALELEA
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005743; C:mitochondrial inner membrane; IDA:MGI
GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl
GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW
GO:0005739; C:mitochondrion; IDA:MGI
GO:0005634; C:nucleus; IEA:Ensembl
GO:0046930; C:pore complex; IEA:UniProtKB-KW
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW
GO:0015288; F:porin activity; IEA:UniProtKB-KW
GO:0008308; F:voltage-gated anion channel activity; IEA:InterPro
GO:2001243; P:negative regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB
GO:0032272; P:negative regulation of protein polymerization; IMP:UniProtKB
Interpro
InterPro; IPR023614; Porin_dom
InterPro; IPR001925; Porin_Euk
InterPro; IPR027246; Porin_Euk/Tom40
Pfam
Pfam; PF01459; Porin_3;
SMART
PROSITE
PROSITE; PS00558; EUKARYOTIC_PORIN;
PRINTS
PRINTS; PR00185; EUKARYTPORIN;