Dispanin subfamily A member 2b; DSPA2b; Fragilis protein; Interferon-inducible protein 15; Mouse ifitm-like protein 1; Mil-1;
Gene Name
Ifitm3
Gene Synonyms/Alias
Created Date
05-OCT-2010
Lipid Modification Sites
Position
Sequence Form
Peptide
References
Modification Type
71
Canonical
NTLFMNFCCLGFIAY
[1]
S-Palmitoylation
72
Canonical
TLFMNFCCLGFIAYA
[1]
S-Palmitoylation
105
Canonical
AYASTAKCLNISTLV
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV) and human immunodeficiency virus type 1 (HIV-1). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state. Involved in initiating germ cell competence and specification, and in the demarcation of PGCs from their somatic neighbors.