| Tag |
Content |
LipidDB ID |
LipidDB-10090-00125 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
5.22 |
Molecular Weight |
9169.14 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
A-kinase anchor protein 7 isoform alpha |
Protein Synonyms/Alias |
AKAP-7 isoform alpha; A-kinase anchor protein 18; AKAP-18; A-kinase anchor protein 9 kDa; AKAP 9; Protein kinase A-anchoring protein 7 isoform alpha; PRKA7 isoform alpha; |
Gene Name |
Akap7 |
Gene Synonyms/Alias |
Akap18; |
Created Date |
30-MAY-2000 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
2 | Canonical | ******MGQLCCFPF | [1] | N-Myristoylation | 5 | Canonical | ***MGQLCCFPFARD | [1] | S-Palmitoylation | 6 | Canonical | **MGQLCCFPFARDE | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD. A novel lipid-anchored A-kinase Anchoring Protein facilitatescAMP-responsive membrane events. EMBO J. 1998 Apr 15;17(8):2261-72.[ PMID:9545239]
|
Functional Description |
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). |
Sequence Annotation |
Region: 2 11 Required for membrane localization.
Region: 29 42 RII-binding.
|
Protein Length |
81 AA. |
Protein Sequence
(Canonical) |
MGQLCCFPFA RDEGKICEKD RREPEDAELV RLSKRLVENA VLKAVQQYLE ETQNKKQPGE 60
GNSTKAEEGD RNGDGSDNNR K 81
MGQLCCFPFA RDEGKICEKD RREPEDAELV RLSKRLVENA VLKAVQQYLE ETQNKKQPGE 60
GNSTKAEEGD RNGDGSDNNR K 81
|
FASTA
(Canonical) |
>LipidDB-10090-00125|O55074
MGQLCCFPFARDEGKICEKDRREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGE
GNSTKAEEGDRNGDGSDNNRK
MGQLCCFPFARDEGKICEKDRREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGE
GNSTKAEEGDRNGDGSDNNRK
|
Gene Ontology |
GO:0005634; C:nucleus; IDA:MGI GO:0005886; C:plasma membrane; IEA:UniProtKB-KW GO:0051018; F:protein kinase A binding; ISS:UniProtKB GO:0019901; F:protein kinase binding; IDA:MGI GO:0008104; P:protein localization; ISA:MGI GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; ISA:MGI |
Interpro |
InterPro; IPR019511; Kinase-A_anchor_RI-RII-bd_dom |
Pfam |
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SMART |
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PROSITE |
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PRINTS |
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