Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00101
Entry Name
UniProt Accession
Theoretical PI
4.8
Molecular Weight
36313.51
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Transmembrane protein 59
Protein Synonyms/Alias
Thymic dendritic cell-derived factor 1;
Gene Name
Tmem59
Gene Synonyms/Alias
ORF18; Tdcf1;
Created Date
26-SEP-2001
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
258
Canonical
MVLLWICCAAVATAV
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding (By similarity).
Sequence Annotation
Topological domain: 36 238 Extracellular.
Transmembrane: 239 259 Helical.
Topological domain: 260 323 Cytoplasmic.
Motif: 263 281 ATG16L1-binding motif.
Protein Length
323 AA.
Protein Sequence
(Canonical)
MAAPKGKLWV QAQLGLPPLL LLTMALAGGS GTAAAEAFDS VLGDTASCHR ACQLTYPLHT  60
YPKEEELYAC QRGCRLFSIC QFVDDGLDLN RTKLECESAC TEAYSQPDEQ YACHLGCQDQ  120
LPFAELRQEQ LMSLMPRMHL LFPLTLVRSF WSDMMDSAQS FITSSWTFYL QADDGKIVIF  180
QSKPEIQYAP QLEQEPTNLR ESSLSKMSYL QMRNSQAHRN YLEEEESDGF LRCLSLNSGW  240
ILTTTLVLSV MVLLWICCAA VATAVEQYVP PEKLSIYGDL EFMNEQKLSR YPAPSLVIVR  300
SQTEEHEEAG PLPTKVNLAH SEI                                          323
FASTA
(Canonical)
>LipidDB-10090-00101|Q9QY73
MAAPKGKLWVQAQLGLPPLLLLTMALAGGSGTAAAEAFDSVLGDTASCHRACQLTYPLHT
YPKEEELYACQRGCRLFSICQFVDDGLDLNRTKLECESACTEAYSQPDEQYACHLGCQDQ
LPFAELRQEQLMSLMPRMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIF
QSKPEIQYAPQLEQEPTNLRESSLSKMSYLQMRNSQAHRNYLEEEESDGFLRCLSLNSGW
ILTTTLVLSVMVLLWICCAAVATAVEQYVPPEKLSIYGDLEFMNEQKLSRYPAPSLVIVR
SQTEEHEEAGPLPTKVNLAHSEI
Gene Ontology
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0000137; C:Golgi cis cisterna; IEA:Ensembl
GO:0005797; C:Golgi medial cisterna; IEA:Ensembl
GO:0000138; C:Golgi trans cisterna; IEA:Ensembl
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005770; C:late endosome; ISS:UniProtKB
GO:0005764; C:lysosome; ISS:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0004175; F:endopeptidase activity; IDA:MGI
GO:0006914; P:autophagy; IEA:UniProtKB-KW
GO:0090005; P:negative regulation of establishment of protein localization to plasma membrane; IEA:Ensembl
GO:0090285; P:negative regulation of protein glycosylation in Golgi; IEA:Ensembl
GO:0010955; P:negative regulation of protein processing; IEA:Ensembl
GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB
GO:0006508; P:proteolysis; IDA:GOC
Interpro
InterPro; IPR022065; Uncharacterised_TMEM59
Pfam
Pfam; PF12280; BSMAP;
SMART
PROSITE
PRINTS