LipidDB ID

LipidDB-10090-00087

Entry Name

UniProt Accession

P05202; O09188; Q3TIP6; Q3UD91; Q5HZH5;

Theoretical PI

9.13

Molecular Weight

47411.38

Genbank Protein ID

AAA37264.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; CAA30015.1; AAA37265.1; AAA37265.1; AAA37265.1; AAA37265.1; AAA37265.1; AAA37265.1; AAA37265.1; AAA37265.1; AAA37265.1; AAB91426.1; BAE23042.1; BAE28248.1; BAE29146.1; BAE29171.1; BAE29370.1; BAE31596.1; BAE33029.1; BAE39800.1; AAH89015.1; AAH89341.1;

Genbank Nucleotide ID

J02622; X06917; X06918; X06919; X06920; X06921; X06922; X06923; X06924; X06925; X06926; M37259; M37250; M37251; M37252; M37253; M37254; M37255; M37256; M37258; U82470; AK136556; AK147953; AK149886; AK149926; AK150194; AK152921; AK155075; AK167767; BC089015; BC089341;

Protein Name

Aspartate aminotransferase, mitochondrial

Protein Synonyms/Alias

mAspAT; 2.6.1.1; 2.6.1.7; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A;

Gene Name

Got2

Gene Synonyms/Alias

Got-2;

Created Date

13-AUG-1987

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Sequence Annotation

Binding site: 65 65 Substrate; via amide nitrogen.
Binding site: 162 162 Substrate.
Binding site: 215 215 Substrate.
Binding site: 407 407 Substrate.
Modified residue: 59 59 N6-acetyllysine.
Modified residue: 73 73 N6-acetyllysine; alternate.
Modified residue: 73 73 N6-succinyllysine; alternate.
Modified residue: 82 82 N6-acetyllysine.
Modified residue: 90 90 N6-acetyllysine; alternate.
Modified residue: 90 90 N6-succinyllysine; alternate.
Modified residue: 96 96 Nitrated tyrosine.
Modified residue: 107 107 N6-acetyllysine; alternate.
Modified residue: 107 107 N6-succinyllysine; alternate.
Modified residue: 122 122 N6-acetyllysine; alternate.
Modified residue: 122 122 N6-succinyllysine; alternate.
Modified residue: 159 159 N6-acetyllysine; alternate.
Modified residue: 159 159 N6-succinyllysine; alternate.
Modified residue: 185 185 N6-acetyllysine; alternate.
Modified residue: 185 185 N6-succinyllysine; alternate.
Modified residue: 227 227 N6-succinyllysine.
Modified residue: 234 234 N6-acetyllysine.
Modified residue: 279 279 N6-(pyridoxal phosphate)lysine;alternate.
Modified residue: 279 279 N6-acetyllysine; alternate.
Modified residue: 296 296 N6-acetyllysine; alternate.
Modified residue: 296 296 N6-succinyllysine; alternate.
Modified residue: 302 302 N6-acetyllysine.
Modified residue: 309 309 N6-acetyllysine; alternate.
Modified residue: 309 309 N6-succinyllysine; alternate.
Modified residue: 338 338 N6-acetyllysine; alternate.
Modified residue: 338 338 N6-succinyllysine; alternate.
Modified residue: 345 345 N6-acetyllysine.
Modified residue: 363 363 N6-acetyllysine; alternate.
Modified residue: 363 363 N6-succinyllysine; alternate.
Modified residue: 364 364 N6-acetyllysine.
Modified residue: 387 387 N6-acetyllysine.
Modified residue: 396 396 N6-acetyllysine; alternate.
Modified residue: 396 396 N6-succinyllysine; alternate.
Modified residue: 404 404 N6-acetyllysine; alternate.
Modified residue: 404 404 N6-succinyllysine; alternate.

Protein Length

430 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005743; C:mitochondrial inner membrane; IDA:MGI
GO:0005739; C:mitochondrion; ISS:UniProtKB
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0016212; F:kynurenine-oxoglutarate transaminase activity; IEA:UniProtKB-EC
GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; ISS:UniProtKB
GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:UniProtKB-EC
GO:0044822; F:poly(A) RNA binding; IEA:Ensembl
GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB
GO:0006532; P:aspartate biosynthetic process; IDA:MGI
GO:0006533; P:aspartate catabolic process; IEA:Ensembl
GO:0006531; P:aspartate metabolic process; ISS:UniProtKB
GO:0015908; P:fatty acid transport; IEA:Ensembl
GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IDA:MGI
GO:0019550; P:glutamate catabolic process to aspartate; IDA:MGI
GO:0006536; P:glutamate metabolic process; ISS:UniProtKB
GO:0006107; P:oxaloacetate metabolic process; IDA:MGI
GO:0045471; P:response to ethanol; IEA:Ensembl

Interpro

InterPro; IPR004839; Aminotransferase_I/II
InterPro; IPR000796; Asp_trans
InterPro; IPR004838; NHTrfase_class1_PyrdxlP-BS
InterPro; IPR015424; PyrdxlP-dep_Trfase
InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1

Pfam

Pfam; PF00155; Aminotran_1_2;

SMART

PROSITE

PROSITE; PS00105; AA_TRANSFER_CLASS_1;

PRINTS

PRINTS; PR00799; TRANSAMINASE;