| Tag |
Content |
LipidDB ID |
LipidDB-10090-00070 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
8.57 |
Molecular Weight |
100526.95 |
Genbank Protein ID |
|
Genbank Nucleotide ID |
|
Protein Name |
Glutamate receptor 3 |
Protein Synonyms/Alias |
GluR-3; AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3; |
Gene Name |
Gria3 |
Gene Synonyms/Alias |
Glur3; Kiaa4184; |
Created Date |
11-OCT-2005 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
841 | Canonical | MVALIEFCYKSRAES | [1] | S-Palmitoylation |
|
Organism |
Mus musculus (Mouse) |
NCBI Taxa ID |
10090 |
Reference |
[1] Hayashi T, Rumbaugh G, Huganir RL. Differential regulation of AMPA receptorsubunit trafficking by palmitoylation of two distinct sites. Neuron. 2005 Sep1;47(5):709-23.[ PMID:16129400]
|
Functional Description |
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). |
Sequence Annotation |
Topological domain: 23 546 Extracellular.
Transmembrane: 547 567 Helical.
Topological domain: 568 596 Cytoplasmic.
Topological domain: 616 621 Cytoplasmic.
Transmembrane: 622 642 Helical.
Topological domain: 643 817 Extracellular.
Transmembrane: 818 838 Helical; Name=M4.
Topological domain: 839 888 Cytoplasmic.
Region: 502 504 Glutamate binding.
Region: 680 681 Glutamate binding.
Binding site: 474 474 Glutamate.
Binding site: 509 509 Glutamate.
Binding site: 731 731 Glutamate.
Modified residue: 871 871 Phosphotyrosine.
Modified residue: 881 881 Phosphotyrosine.
|
Protein Length |
888 AA. |
Protein Sequence
(Canonical) |
MGQSVLRAVF FLVLGLLGHS HGGFPNTISI GGLFMRNTVQ EHSAFRFAVQ LYNTNQNTTE 60
KPFHLNYHVD HLDSSNSFSV TNAFCSQFSR GVYAIFGFYD QMSMNTLTSF CGALHTSFVT 120
PSFPTDADVQ FVIQMRPALK GAILSLLGYY KWEKFVYLYD TERGFSILQA IMEAAVQNNW 180
QVTARSVGNI KDIQEFRRII EEMDRRQEKR YLIDCEVERI NTILEQVVIL GKHSRGYHYM 240
LANLGFTDIV LERVMHGGAN ITGFQIVNNE NPMVQQFIQR WVRLDEREFP EAKNAPLKYT 300
SALTHDAILV IAEAFRYLRR QRVDVSRRGS AGDCLANPAV PWSQGIDIER ALKMVQVQGM 360
TGNIQFDTYG RRTNYTIDVY EMKVSGSRKA GYWNEYERFV PFSDQQISND SSSSENRTIV 420
VTTILESPYV MYKKNHEQLE GNERYEGYCV DLAYEIAKHV RIKYKLSIVG DGKYGARDPE 480
TKIWNGMVGE LVYGRADIAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS 540
FLDPLAYEIW MCIVFAYIGV SVVLFLVSRF SPYEWHLEDN NEEPRDPQSP PDPPNEFGIF 600
NSLWFSLGAF MQQGCDISPR SLSGRIVGGV WWFFTLIIIS SYTANLAAFL TVERMVSPIE 660
SAEDLAKQTE IAYGTLDSGS TKEFFRRSKI AVYEKMWSYM KSAEPSVFTK TTADGVARVR 720
KSKGKFAFLL ESTMNEYIEQ RKPCDTMKVG GNLDSKGYGV ATPKGSALRT PVNLAVLKLS 780
EQGILDKLKN KWWYDKGECG AKDSGSKDKT SALSLSNVAG VFYILVGGLG LAMMVALIEF 840
CYKSRAESKR MKLTKNTQNF KPAPATNTQN YATYREGYNV YGTESVKI 888
|
FASTA
(Canonical) |
>LipidDB-10090-00070|Q9Z2W9
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTE
KPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVT
PSFPTDADVQFVIQMRPALKGAILSLLGYYKWEKFVYLYDTERGFSILQAIMEAAVQNNW
QVTARSVGNIKDIQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYM
LANLGFTDIVLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYT
SALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGM
TGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIV
VTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPE
TKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFS
FLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIF
NSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIE
SAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVR
KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLS
EQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEF
CYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
|
Gene Ontology |
GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; ISS:UniProtKB GO:0030054; C:cell junction; IEA:UniProtKB-KW GO:0030425; C:dendrite; IBA:RefGenome GO:0016020; C:membrane; IDA:MGI GO:0045211; C:postsynaptic membrane; IDA:MGI GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:UniProtKB GO:0005234; F:extracellular-glutamate-gated ion channel activity; IBA:RefGenome GO:0034220; P:ion transmembrane transport; IBA:RefGenome GO:0035235; P:ionotropic glutamate receptor signaling pathway; IBA:RefGenome GO:0035249; P:synaptic transmission, glutamatergic; IBA:RefGenome |
Interpro |
|
Pfam |
|
SMART |
|
PROSITE |
|
PRINTS |
|