Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00063
Entry Name
UniProt Accession
Theoretical PI
6.0
Molecular Weight
115374.53
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Sn1-specific diacylglycerol lipase alpha
Protein Synonyms/Alias
DGL-alpha; 3.1.1.-; Neural stem cell-derived dendrite regulator;
Gene Name
Dagla
Gene Synonyms/Alias
Kiaa0659; Nsddr;
Created Date
05-SEP-2006
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
324
Canonical
LCQLARSCSCCLCPA
[1]
S-Palmitoylation
619
Canonical
NHPAEQCCCCEQEEP
[1]
S-Palmitoylation
620
Canonical
HPAEQCCCCEQEEPT
[1]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Predicted from GPS-Lipid
Functional Description
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity).
Sequence Annotation
Topological domain: 1 22 Cytoplasmic.
Transmembrane: 23 43 Helical.
Topological domain: 44 60 Extracellular.
Transmembrane: 61 81 Helical.
Topological domain: 82 101 Cytoplasmic.
Transmembrane: 102 122 Helical.
Topological domain: 123 136 Extracellular.
Transmembrane: 137 157 Helical.
Topological domain: 158 1044 Cytoplasmic.
Active site: 472 472 Charge relay system.
Active site: 524 524 Charge relay system.
Modified residue: 733 733 Phosphoserine.
Modified residue: 744 744 Phosphoserine.
Protein Length
1044 AA.
Protein Sequence
(Canonical)
MPGIVVFRRR WSVGSDDLVL PAIFLFLLHT TWFVILSVVL FGLVYNPHEA CSLNLVDHGR  60
GYLGILLSCM IAEMAIIWLS MRGGILYTEP RDSMQYVLYV RLAILVIEFI YAIVGIVWLT  120
QYYTSCNDLT AKNVTLGMVV CNWVVILSVC ITVLCVFDPT GRTFVKLRAT KRRQRNLRTY  180
NLRHRLEEGQ ATSWSRRLKV FLCCTRTKDS QSDAYSEIAY LFAEFFRDLD IVPSDIIAGL  240
VLLRQRQRAK RNAVLDEANN DILAFLSGMP VTRNTKYLDL KNSHEMLRYK EVCYYMLFAL  300
AAYGWPMYLM RKPTCGLCQL ARSCSCCLCP ARPRFAPGVT IEEDNCCGCN AIAIRRHFLD  360
ENMTAVDIVY TSCHDAVYET PFYVAVDHDK KKVVISIRGT LSPKDALTDL TGDAERLPVE  420
GHRGTWLGHK GMVLSAEYIK KKLEQEMVLS QAFGRDLGRG TKHYGLIVVG HSLGAGTAAI  480
LSFLLRPQYP TLKCFAYSPP GGLLSEDAME YSKEFVTAVV LGKDLVPRIG LSQLEGFRRQ  540
LLDVLQRSTK PKWRIIVGAT KCIPKSELPE DQVEVTTLAS TRLWTHPSDL TIALSASTPL  600
YPPGRIIHVV HNHPAEQCCC CEQEEPTYFA IWGDNKAFNE VIISPAMLHE HLPYVVMEGL  660
NKVLENYNKG KTALLSAAKV MVSPTEVDLT PELIFQQQPL PTGPPLPTGL ALELPATEHR  720
NSSVRSKSQS EMSLEGFSEG RLLSPVAAAS AARQDPVELL LLSTQERLAA ELQSRRAPLA  780
TMESLSDTES LYSFDSRRSS GFRSIRGSPS LHAVLERDEG HLFYIDPAIP EENPSLSSRT  840
ELLAADSLSK HSQDTQPLEA ALGSGGVTPE RPPSATIEEE EAAGGSEGGG VAPRGELALH  900
NGRLGDSPSP QVLEFAEFID SLFNLDSKSS SFQDLYCMMV PESPTSDYTE GPKSPSQQEI  960
LLRAQFEPNL VPKPPRLFAG SAEPSSGISL SPSFPLSSSG ELMDLTPTGL SSQECLATDK  1020
IRTSTPTGHG ASPTKQDDLV ISAR                                         1044
FASTA
(Canonical)
>LipidDB-10090-00063|Q6WQJ1
MPGIVVFRRRWSVGSDDLVLPAIFLFLLHTTWFVILSVVLFGLVYNPHEACSLNLVDHGR
GYLGILLSCMIAEMAIIWLSMRGGILYTEPRDSMQYVLYVRLAILVIEFIYAIVGIVWLT
QYYTSCNDLTAKNVTLGMVVCNWVVILSVCITVLCVFDPTGRTFVKLRATKRRQRNLRTY
NLRHRLEEGQATSWSRRLKVFLCCTRTKDSQSDAYSEIAYLFAEFFRDLDIVPSDIIAGL
VLLRQRQRAKRNAVLDEANNDILAFLSGMPVTRNTKYLDLKNSHEMLRYKEVCYYMLFAL
AAYGWPMYLMRKPTCGLCQLARSCSCCLCPARPRFAPGVTIEEDNCCGCNAIAIRRHFLD
ENMTAVDIVYTSCHDAVYETPFYVAVDHDKKKVVISIRGTLSPKDALTDLTGDAERLPVE
GHRGTWLGHKGMVLSAEYIKKKLEQEMVLSQAFGRDLGRGTKHYGLIVVGHSLGAGTAAI
LSFLLRPQYPTLKCFAYSPPGGLLSEDAMEYSKEFVTAVVLGKDLVPRIGLSQLEGFRRQ
LLDVLQRSTKPKWRIIVGATKCIPKSELPEDQVEVTTLASTRLWTHPSDLTIALSASTPL
YPPGRIIHVVHNHPAEQCCCCEQEEPTYFAIWGDNKAFNEVIISPAMLHEHLPYVVMEGL
NKVLENYNKGKTALLSAAKVMVSPTEVDLTPELIFQQQPLPTGPPLPTGLALELPATEHR
NSSVRSKSQSEMSLEGFSEGRLLSPVAAASAARQDPVELLLLSTQERLAAELQSRRAPLA
TMESLSDTESLYSFDSRRSSGFRSIRGSPSLHAVLERDEGHLFYIDPAIPEENPSLSSRT
ELLAADSLSKHSQDTQPLEAALGSGGVTPERPPSATIEEEEAAGGSEGGGVAPRGELALH
NGRLGDSPSPQVLEFAEFIDSLFNLDSKSSSFQDLYCMMVPESPTSDYTEGPKSPSQQEI
LLRAQFEPNLVPKPPRLFAGSAEPSSGISLSPSFPLSSSGELMDLTPTGLSSQECLATDK
IRTSTPTGHGASPTKQDDLVISAR
Gene Ontology
GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW
GO:0005886; C:plasma membrane; IEA:UniProtKB-KW
GO:0043196; C:varicosity; IDA:MGI
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW
GO:0019369; P:arachidonic acid metabolic process; IMP:MGI
GO:0046340; P:diacylglycerol catabolic process; IEA:Ensembl
GO:0071926; P:endocannabinoid signaling pathway; IMP:MGI
GO:0007405; P:neuroblast proliferation; IMP:MGI
GO:0022008; P:neurogenesis; IMP:MGI
GO:0042136; P:neurotransmitter biosynthetic process; IMP:MGI
Interpro
InterPro; IPR029058; AB_hydrolase
InterPro; IPR002921; Fungal_lipase-like
Pfam
Pfam; PF01764; Lipase_3;
SMART
PROSITE
PROSITE; PS00120; LIPASE_SER;
PRINTS