Lipid Modification Database
Tag Content
LipidDB ID
LipidDB-10090-00029
Entry Name
UniProt Accession
Theoretical PI
8.35
Molecular Weight
39257.55
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
Protein Wnt-3a
Protein Synonyms/Alias
Gene Name
Wnt3a
Gene Synonyms/Alias
Wnt-3a;
Created Date
01-AUG-1992
 Lipid Modification Sites 
 Position   Sequence Form   Peptide   References   Modification Type 
77
Canonical
VKAGIQECQHQFRGR
[1][2]
S-Palmitoylation
Organism
Mus musculus (Mouse)
NCBI Taxa ID
10090
Reference
[1] Komekado H, Yamamoto H, Chiba T, Kikuchi A. Glycosylation and palmitoylationof Wnt-3a are coupled to produce an active form of Wnt-3a. Genes Cells. 2007Apr;12(4):521-34.[PMID:17397399]
[2] Galli LM, Barnes TL, Secrest SS, Kadowaki T, Burrus LW. Porcupine-mediatedlipid-modification regulates the activity and distribution of Wnt proteins in thechick neural tube. Development. 2007 Sep;134(18):3339-48.[PMID:17720697]
Functional Description
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Sequence Annotation
Functional site: 26 27 Cleavage; by TIKI1 and TIKI2.
Protein Length
352 AA.
Protein Sequence
(Canonical)
MAPLGYLLVL CSLKQALGSY PIWWSLAVGP QYSSLSTQPI LCASIPGLVP KQLRFCRNYV  60
EIMPSVAEGV KAGIQECQHQ FRGRRWNCTT VSNSLAIFGP VLDKATRESA FVHAIASAGV  120
AFAVTRSCAE GSAAICGCSS RLQGSPGEGW KWGGCSEDIE FGGMVSREFA DARENRPDAR  180
SAMNRHNNEA GRQAIASHMH LKCKCHGLSG SCEVKTCWWS QPDFRTIGDF LKDKYDSASE  240
MVVEKHRESR GWVETLRPRY TYFKVPTERD LVYYEASPNF CEPNPETGSF GTRDRTCNVS  300
SHGIDGCDLL CCGRGHNART ERRREKCHCV FHWCCYVSCQ ECTRVYDVHT CK          352
FASTA
(Canonical)
>LipidDB-10090-00029|P27467
MAPLGYLLVLCSLKQALGSYPIWWSLAVGPQYSSLSTQPILCASIPGLVPKQLRFCRNYV
EIMPSVAEGVKAGIQECQHQFRGRRWNCTTVSNSLAIFGPVLDKATRESAFVHAIASAGV
AFAVTRSCAEGSAAICGCSSRLQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDAR
SAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRTIGDFLKDKYDSASE
MVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVS
SHGIDGCDLLCCGRGHNARTERRREKCHCVFHWCCYVSCQECTRVYDVHTCK
Gene Ontology
GO:0009986; C:cell surface; IDA:BHF-UCL
GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome
GO:0005615; C:extracellular space; IDA:BHF-UCL
GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-KW
GO:0005109; F:frizzled binding; IPI:MGI
GO:0005110; F:frizzled-2 binding; IDA:MGI
GO:0019904; F:protein domain specific binding; IPI:UniProtKB
GO:0005102; F:receptor binding; TAS:MGI
GO:0003713; F:transcription coactivator activity; IDA:UniProtKB
GO:0009952; P:anterior/posterior pattern specification; IDA:MGI
GO:0090245; P:axis elongation involved in somitogenesis; IGI:MGI
GO:0007411; P:axon guidance; IDA:MGI
GO:0007409; P:axonogenesis; IDA:MGI
GO:0030509; P:BMP signaling pathway; ISO:MGI
GO:0060070; P:canonical Wnt signaling pathway; IDA:UniProtKB
GO:0061317; P:canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; IEA:Ensembl
GO:0060923; P:cardiac muscle cell fate commitment; IGI:MGI
GO:0021846; P:cell proliferation in forebrain; IDA:BHF-UCL
GO:0007267; P:cell-cell signaling; TAS:MGI
GO:0034613; P:cellular protein localization; IDA:MGI
GO:0010387; P:COP9 signalosome assembly; IDA:BHF-UCL
GO:0007368; P:determination of left/right symmetry; IMP:MGI
GO:0021904; P:dorsal/ventral neural tube patterning; IMP:MGI
GO:0030198; P:extracellular matrix organization; IDA:MGI
GO:0001947; P:heart looping; IMP:MGI
GO:0030097; P:hemopoiesis; IDA:MGI
GO:0021766; P:hippocampus development; IMP:MGI
GO:0001701; P:in utero embryonic development; IMP:MGI
GO:0042472; P:inner ear morphogenesis; IGI:MGI
GO:0030879; P:mammary gland development; IDA:MGI
GO:0007498; P:mesoderm development; IMP:MGI
GO:0048843; P:negative regulation of axon extension involved in axon guidance; IDA:MGI
GO:0045599; P:negative regulation of fat cell differentiation; IDA:MGI
GO:0003136; P:negative regulation of heart induction by canonical Wnt signaling pathway; IEA:Ensembl
GO:0050768; P:negative regulation of neurogenesis; IDA:BHF-UCL
GO:0010977; P:negative regulation of neuron projection development; IDA:UniProtKB
GO:0009887; P:organ morphogenesis; TAS:MGI
GO:0001649; P:osteoblast differentiation; IGI:MGI
GO:0060021; P:palate development; IEA:Ensembl
GO:0048343; P:paraxial mesodermal cell fate commitment; IMP:MGI
GO:0030168; P:platelet activation; IDA:MGI
GO:0070527; P:platelet aggregation; IDA:MGI
GO:0030890; P:positive regulation of B cell proliferation; IDA:MGI
GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:MGI
GO:2000081; P:positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; IDA:UniProtKB
GO:2000727; P:positive regulation of cardiac muscle cell differentiation; IEA:Ensembl
GO:0035413; P:positive regulation of catenin import into nucleus; IEA:Ensembl
GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB
GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IDA:MGI
GO:0048697; P:positive regulation of collateral sprouting in absence of injury; IDA:MGI
GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI
GO:0061184; P:positive regulation of dermatome development; IEA:Ensembl
GO:0048337; P:positive regulation of mesodermal cell fate specification; IEA:Ensembl
GO:2000179; P:positive regulation of neural precursor cell proliferation; IDA:MGI
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl
GO:0032092; P:positive regulation of protein binding; IEA:Ensembl
GO:0061098; P:positive regulation of protein tyrosine kinase activity; IGI:MGI
GO:0002092; P:positive regulation of receptor internalization; IEA:Ensembl
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI
GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB
GO:0036342; P:post-anal tail morphogenesis; IMP:MGI
GO:0050770; P:regulation of axonogenesis; IGI:MGI
GO:0045595; P:regulation of cell differentiation; IDA:MGI
GO:0070507; P:regulation of microtubule cytoskeleton organization; IGI:MGI
GO:0007165; P:signal transduction; TAS:MGI
GO:0035914; P:skeletal muscle cell differentiation; IGI:MGI
GO:0048103; P:somatic stem cell division; IDA:MGI
GO:0001756; P:somitogenesis; IMP:MGI
GO:0021527; P:spinal cord association neuron differentiation; IDA:MGI
GO:0016055; P:Wnt signaling pathway; IGI:MGI
GO:0021874; P:Wnt signaling pathway involved in forebrain neuroblast division; IMP:MGI
Interpro
InterPro; IPR005817; Wnt
InterPro; IPR009141; Wnt3
InterPro; IPR018161; Wnt_CS
Pfam
Pfam; PF00110; wnt;
SMART
SMART; SM00097; WNT1;
PROSITE
PROSITE; PS00246; WNT1;
PRINTS
PRINTS; PR01843; WNT3PROTEIN;
PRINTS; PR01349; WNTPROTEIN;