LipidDB ID

LipidDB-10090-00019

Entry Name

UniProt Accession

P63321; P05810;

Theoretical PI

6.66

Molecular Weight

23552.77

Genbank Protein ID

CAA88488.1; AAG23136.1; AAH31741.1;

Genbank Nucleotide ID

Z48587; AF244951; BC031741;

Protein Name

Ras-related protein Ral-A

Protein Synonyms/Alias

Gene Name

Rala

Gene Synonyms/Alias

Ral; Ral-a;

Created Date

11-OCT-2004

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Predicted from GPS-Lipid

Functional Description

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). The RALA- exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.

Sequence Annotation

Nucleotide-binding: 21 28 GTP.
Nucleotide-binding: 68 72 GTP.
Nucleotide-binding: 127 130 GTP.
Motif: 43 51 Effector region.
Modified residue: 203 203 Cysteine methyl ester.

Protein Length

206 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0032154; C:cleavage furrow; ISS:UniProtKB
GO:0030659; C:cytoplasmic vesicle membrane; TAS:Reactome
GO:0030139; C:endocytic vesicle; IEA:Ensembl
GO:0070062; C:extracellular vesicular exosome; IEA:Ensembl
GO:0005886; C:plasma membrane; ISS:UniProtKB
GO:0031755; F:Edg-2 lysophosphatidic acid receptor binding; ISS:UniProtKB
GO:0005525; F:GTP binding; IEA:UniProtKB-KW
GO:0003924; F:GTPase activity; IEA:InterPro
GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl
GO:0000910; P:cytokinesis; ISS:UniProtKB
GO:0006887; P:exocytosis; IEA:UniProtKB-KW
GO:0051665; P:membrane raft localization; IDA:UniProtKB
GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl
GO:0007265; P:Ras protein signal transduction; IEA:InterPro
GO:0017157; P:regulation of exocytosis; IDA:UniProtKB

Interpro

InterPro; IPR027417; P-loop_NTPase
InterPro; IPR028412; Ral
InterPro; IPR005225; Small_GTP-bd_dom
InterPro; IPR001806; Small_GTPase
InterPro; IPR020849; Small_GTPase_Ras

Pfam

Pfam; PF00071; Ras;

SMART

SMART; SM00173; RAS;

PROSITE

PROSITE; PS51421; RAS;

PRINTS

PRINTS; PR00449; RASTRNSFRMNG;