LipidDB ID

LipidDB-10090-00009

Entry Name

UniProt Accession

Q64264; Q60956; Q61617; Q8BGS4;

Theoretical PI

9.15

Molecular Weight

46175.97

Genbank Protein ID

AAA81519.1; BAC31611.1; BAC33931.1; BAC33970.1; BAE24273.1; EDL18479.1; AAI38670.1; AAI38682.1; AAC52572.1; AAA16850.1;

Genbank Nucleotide ID

U39391; AK043668; AK049814; AK049884; AK140194; CH466568; BC138669; BC138681; U33820; L20339;

Protein Name

5-hydroxytryptamine receptor 1A

Protein Synonyms/Alias

5-HT-1A; 5-HT1A; Serotonin receptor 1A;

Gene Name

Htr1a

Gene Synonyms/Alias

Gpcr18;

Created Date

01-NOV-1997

Organism

Mus musculus (Mouse)

NCBI Taxa ID

10090

Reference

[1] Papoucheva E, Dumuis A, Sebben M, Richter DW, Ponimaskin EG. The5-hydroxytryptamine(1A) receptor is stably palmitoylated, and acylation iscritical for communication of receptor with Gi protein. J Biol Chem. 2004 Jan30;279(5):3280-91. Epub 2003 Nov 6.[PMID:14604995]

Functional Description

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Sequence Annotation

Topological domain: 1 36 Extracellular.
Transmembrane: 37 62 Helical; Name=1.
Topological domain: 63 73 Cytoplasmic.
Transmembrane: 74 98 Helical; Name=2.
Topological domain: 99 110 Extracellular.
Transmembrane: 111 132 Helical; Name=3.
Topological domain: 133 152 Cytoplasmic.
Transmembrane: 153 178 Helical; Name=4.
Topological domain: 179 191 Extracellular.
Transmembrane: 192 217 Helical; Name=5.
Topological domain: 218 345 Cytoplasmic.
Transmembrane: 346 367 Helical; Name=6.
Topological domain: 368 378 Extracellular.
Transmembrane: 379 403 Helical; Name=7.
Topological domain: 404 421 Cytoplasmic.
Region: 112 121 Agonist binding.
Region: 358 362 Agonist binding.
Motif: 133 135 DRY motif; important for ligand-inducedconformation changes.
Motif: 396 400 NPxxY motif; important for ligand-inducedconformation changes and signaling.

Protein Length

421 AA.

Protein Sequence
(Canonical)

FASTA
(Canonical)

Gene Ontology

GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB
GO:0004993; F:serotonin receptor activity; IMP:UniProtKB
GO:0007198; P:adenylate cyclase-inhibiting serotonin receptor signaling pathway; ISS:UniProtKB
GO:0001662; P:behavioral fear response; IMP:UniProtKB
GO:0008283; P:cell proliferation; IEA:InterPro
GO:0035640; P:exploration behavior; IMP:UniProtKB
GO:0050795; P:regulation of behavior; IEA:InterPro
GO:0042053; P:regulation of dopamine metabolic process; IMP:UniProtKB
GO:0046883; P:regulation of hormone secretion; IEA:InterPro
GO:0014062; P:regulation of serotonin secretion; IMP:UniProtKB
GO:0042428; P:serotonin metabolic process; IMP:UniProtKB
GO:0007210; P:serotonin receptor signaling pathway; IMP:UniProtKB
GO:0042310; P:vasoconstriction; IEA:InterPro

Interpro

InterPro; IPR000610; 5HT1A_rcpt
InterPro; IPR002231; 5HT_rcpt
InterPro; IPR000276; GPCR_Rhodpsn
InterPro; IPR017452; GPCR_Rhodpsn_7TM

Pfam

Pfam; PF00001; 7tm_1;

SMART

PROSITE

PROSITE; PS00237; G_PROTEIN_RECEP_F1_1;
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2;

PRINTS

PRINTS; PR00512; 5HT1ARECEPTR;
PRINTS; PR01101; 5HTRECEPTOR;
PRINTS; PR00237; GPCRRHODOPSN;