| Tag |
Content |
LipidDB ID |
LipidDB-10029-01456 |
Entry Name |
|
UniProt Accession |
|
Theoretical PI |
4.22 |
Molecular Weight |
32627.11 |
Genbank Protein ID |
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Genbank Nucleotide ID |
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Protein Name |
Peroxisomal biogenesis factor 19 |
Protein Synonyms/Alias |
Peroxin-19; Peroxisomal farnesylated protein; |
Gene Name |
PEX19 |
Gene Synonyms/Alias |
PXF; |
Created Date |
15-JUL-1998 |
| Lipid Modification Sites |
|---|
| Position |
Sequence Form |
Peptide |
References |
Modification Type |
296 | Canonical | PGANGEQCLIM**** | [1] | S-Farnesylation |
|
Organism |
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) |
NCBI Taxa ID |
10029 |
Reference |
[1] James GL, Goldstein JL, Pathak RK, Anderson RG, Brown MS. PxF, a prenylatedprotein of peroxisomes. J Biol Chem. 1994 May 13;269(19):14182-90.[ PMID:8188701]
|
Functional Description |
Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (By similarity). |
Sequence Annotation |
Region: 2 91 Necessary for PEX19 function onperoxisome biogenesis.
Region: 2 56 Docking to the peroxisome membrane andbinding to PEX3.
Modified residue: 2 2 N-acetylalanine.
Modified residue: 35 35 Phosphoserine.
Modified residue: 296 296 Cysteine methyl ester.
|
Protein Length |
299 AA. |
Protein Sequence
(Canonical) |
MAAAEEGCDA GVEADRELEE LLESALDDFD KAKPSPAPPP TTSAPDASGP QKKSPGDTAK 60
DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDAN 120
SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE EELTKAMEGL GMDDGDGDGN ILPIMQSIMQ 180
NLLSKDVLYP SLKEITEKYP EWLQSHQESI PPEQFEKYQE QHSVMGKICE QFEAETPTDS 240
EATHRARFEA VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DTLNLSGPPG ANGEQCLIM 299
|
FASTA
(Canonical) |
>LipidDB-10029-01456|Q60415
MAAAEEGCDAGVEADRELEELLESALDDFDKAKPSPAPPPTTSAPDASGPQKKSPGDTAK
DALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDAN
SQQEFTSCLKETLSGLAKNATDLQNSGMSEEELTKAMEGLGMDDGDGDGNILPIMQSIMQ
NLLSKDVLYPSLKEITEKYPEWLQSHQESIPPEQFEKYQEQHSVMGKICEQFEAETPTDS
EATHRARFEAVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDTLNLSGPPGANGEQCLIM
|
Gene Ontology |
GO:0005737; C:cytoplasm; ISS:UniProtKB GO:0016021; C:integral component of membrane; ISS:UniProtKB GO:0005634; C:nucleus; ISS:UniProtKB GO:0005778; C:peroxisomal membrane; ISS:UniProtKB GO:0016557; P:peroxisome membrane biogenesis; ISS:UniProtKB GO:0007031; P:peroxisome organization; ISS:UniProtKB GO:0006625; P:protein targeting to peroxisome; ISS:UniProtKB |
Interpro |
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Pfam |
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SMART |
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PROSITE |
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PRINTS |
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